Searching journal content for articles similar to Pickeral et al. 10 (4): 411.

Displaying results 1-10 of 49

For checked items

view abstracts
download to citation manager

Select this article
Research: Locus-resolution analysis of L1 regulation and retrotransposition potential in mouse embryonic development
- Patricia Gerdes,
- Dorothy Chan,
- Mischa Lundberg,
- Francisco J. Sanchez-Luque,
- Gabriela O. Bodea,
- Adam D. Ewing,
- Geoffrey J. Faulkner,
- and Sandra R. Richardson
Genome Res. September 2023 33: 1465-1481; Published in Advance October 5, 2023, doi:10.1101/gr.278003.123
..., and stability.Retrotransposons are major contributors to ongoing mutagenesis in mammalian s. The autonomous non-long terminal repeat (non-LTR) retrotransposon Long Interspersed Element 1 (LINE-1 or L1) is actively mobilizing in both humans and mice, and L1 sequences occupy ∼17% of human DNA and ∼18% of mouse...
OPEN ACCESS ARTICLE
Select this article
Research: Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers
- Hyunchul Jung,
- Jung Kyoon Choi,
- and Eunjung Alice Lee
Genome Res. August 2018 28: 1136-1146; Published in Advance July 3, 2018, doi:10.1101/gr.231837.117
....lee@childrens.harvard.edu, jungkyoon@kaist.ac.krAbstractLong interspersed nuclear element-1 (LINE-1 or L1) retrotransposons are normally suppressed in somatic tissues mainly due to DNA methylation and antiviral defense. However, the mechanism to suppress L1s may be disrupted in cancers, thus allowing L1s to act as insertional...
OPEN ACCESS ARTICLE
Select this article
Research: L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis
- Stephanie N. Schauer,
- Patricia E. Carreira,
- Ruchi Shukla,
- Daniel J. Gerhardt,
- Patricia Gerdes,
- Francisco J. Sanchez-Luque,
- Paola Nicoli,
- Michaela Kindlova,
- Serena Ghisletti,
- Alexandre Dos Santos,
- Delphine Rapoud,
- Didier Samuel,
- Jamila Faivre,
- Adam D. Ewing,
- Sandra R. Richardson,
- and Geoffrey J. Faulkner
Genome Res. May 2018 28: 639-653; Published in Advance April 11, 2018, doi:10.1101/gr.226993.117
...Element-1 (LINE-1 or L1), which accounts for 19.9% and 17.5% of mouse and human genomic DNA, respectively (Smit et al. 2013). Although the vast majority of L1 copies are no longer mobile, 80–100 human L1s and 2000–3000 mouse L1s, per individual, are full-length and retain retrotransposition potential...
OPEN ACCESS ARTICLE
Select this article
Resource: Genetic features and genomic targets of human KRAB-zinc finger proteins
- Jonas de Tribolet-Hardy,
- Christian W. Thorball,
- Romain Forey,
- Evarist Planet,
- Julien Duc,
- Alexandre Coudray,
- Bara Khubieh,
- Sandra Offner,
- Cyril Pulver,
- Jacques Fellay,
- Michael Imbeault,
- Priscilla Turelli,
- and Didier Trono
Genome Res. August 2023 33: 1409-1423; Published in Advance September 20, 2023, doi:10.1101/gr.277722.123
...and Goff 2009; Jacobs et al. 2014; Najafabadi et al. 2015; Schmitges et al. 2016; Imbeault et al. 2017; Bruno et al. 2019). TE-derived sequences make up a readily recognizable 50% of the human genomic DNA, a likely underestimation of their real contribution to our genetic makeup as their signature features...
OPEN ACCESS ARTICLE
Select this article
Research: Heritable L1 retrotransposition in the mouse primordial germline and early embryo
- Sandra R. Richardson,
- Patricia Gerdes,
- Daniel J. Gerhardt,
- Francisco J. Sanchez-Luque,
- Gabriela-Oana Bodea,
- Martin Muñoz-Lopez,
- J. Samuel Jesuadian,
- Marie-Jeanne H.C. Kempen,
- Patricia E. Carreira,
- Jeffrey A. Jeddeloh,
- Jose L. Garcia-Perez,
- Haig H. Kazazian, Jr.,
- Adam D. Ewing,
- and Geoffrey J. Faulkner
Genome Res. August 2017 27: 1395-1405; Published in Advance May 8, 2017, doi:10.1101/gr.219022.116
...; Kopera et al. 2016). Full details of the cultured cell retrotransposition assay can be found in Supplemental Methods. Mosaicism analysis qPCR Quantitative PCR using genomic DNA as template was carried out using primers and dual-labeled PrimeTime qPCR probes (5′ 6-FAMZEN-3′ Iowa Black FQ) from IDT...
OPEN ACCESS ARTICLE
Select this article
Resource: Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression
- Ni-Chen Chang,
- Quirze Rovira,
- Jonathan Wells,
- Cédric Feschotte,
- and Juan M. Vaquerizas
Genome Res. July 2022 32: 1408-1423; Published in Advance January 5, 2022, doi:10.1101/gr.275655.121
...transposons are more frequently found nearby or within genes. Locus-specific mapping of TE expression reveals extensive TE transcription during development. Although two-thirds of TE transcripts are likely driven by nearby gene promoters, we still observe stage- and tissue-specific expression patterns in self...
OPEN ACCESS ARTICLE
Select this article
Research: Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites
- Fiorella C. Grandi,
- James M. Rosser,
- Simon J. Newkirk,
- Jun Yin,
- Xiaoling Jiang,
- Zhuo Xing,
- Leanne Whitmore,
- Sanum Bashir,
- Zoltán Ivics,
- Zsuzsanna Izsvák,
- Ping Ye,
- Y. Eugene Yu,
- and Wenfeng An
Genome Res. August 2015 25: 1135-1146; Published in Advance May 20, 2015, doi:10.1101/gr.185132.114
.... However, little is known about the epigenetic impact of newly inserted CGIs. We utilized a transgenic LINE-1 mouse model and tracked DNA methylation dynamics of individual germline insertions during mouse development. The retrotransposed GFP marker sequence, a strong CGI, is hypomethylated in male germ...
OPEN ACCESS ARTICLE
Select this article
Research: Transposon expression in the Drosophila brain is driven by neighboring genes and diversifies the neural transcriptome
- Christoph D. Treiber and
- Scott Waddell
Genome Res. November 2020 30: 1559-1569; Published in Advance September 24, 2020, doi:10.1101/gr.259200.119
...in the Doc-cluster had high Furin 1 (Fur1) (Fig. 1I). Referring back to the gDNA revealed that αβCherry flies harbor a Stalker2 copy within Hsp70Bc and a LINE-like Doc element inside Fur1. Again, these data suggest expression of Stalker2 and Doc is driven by a neighboring gene.Quantitative analysis reveals...
OPEN ACCESS ARTICLE
Select this article
Research: Extensive somatic L1 retrotransposition in colorectal tumors
- Szilvia Solyom,
- Adam D. Ewing,
- Eric P. Rahrmann,
- Tara Doucet,
- Heather H. Nelson,
- Michael B. Burns,
- Reuben S. Harris,
- David F. Sigmon,
- Alex Casella,
- Bracha Erlanger,
- Sarah Wheelan,
- Kyle R. Upton,
- Ruchi Shukla,
- Geoffrey J. Faulkner,
- David A. Largaespada,
- and Haig H. Kazazian, Jr.
Genome Res. December 2012 22: 2328-2338; Published in Advance September 11, 2012, doi:10.1101/gr.145235.112
...are the addition of a new poly(A) tail to the integrated sequence and target-site duplication (TSD), usually 6–20 bp in length. A fraction of retrotransposition events are also associated with 39 transduction, the comobilization of 39 flanking DNA sequences (Holmes et al. 1994; Moran et al. 1999; Goodier et al...
Select this article
Research: Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing
- Elena Helman,
- Michael S. Lawrence,
- Chip Stewart,
- Carrie Sougnez,
- Gad Getz,
- and Matthew Meyerson
Genome Res. July 2014 24: 1053-1063; Published in Advance May 13, 2014, doi:10.1101/gr.163659.113
..., Eichler EE, Badge RM, Moran JV. 2010. LINE-1 retrotransposition activity in human s. Cell 141: 1159–1170. Belgnaoui SM, Gosden RG, Semmes OJ, Haoudi A. 2006. Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells. Cancer Cell Int 6: 13. Beroukhim R, Getz G, Nghiemphu L, Barretina J...

For checked items

view abstracts
download to citation manager

Searching journal content for articles similar to Pickeral et al. 10 (4): 411.

Search Results

Modify Results

This search

Preprint Server

Current Issue

In This Issue

Citation format:
Results / page:
Results order: