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Peterson et al. 9 (9): 844
.
Displaying results 1-10 of
4233
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Method
:
A spectral component approach leveraging identity-by-descent graphs to address recent population structure in genomic analysis
Ruhollah Shemirani
,
Gillian M. Belbin
,
Sinead Cullina
,
Christa Caggiano
,
Christopher R. Gignoux
,
Noah Zaitlen
,
and
Eimear E. Kenny
Genome Res.
March 2026
36
:
534
-
546
;
Published in Advance
December 23, 2025
,
doi:
10.1101/gr.280659.125
...variants into causal and noncausal, referring to variants neither truly associated with the phenotype nor in
linkage
disequilibrium
(LD) with causal variants. We assumed that any systematic differences in calculated P-values or effect sizes of noncausal variants in between the two models are likely owing...
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Research
:
Most chromatin interactions are not in linkage disequilibrium
Sean Whalen
and
Katherine S. Pollard
Genome Res.
March 2019
29
:
334
-
343
;
Published in Advance
January 7, 2019
,
doi:
10.1101/gr.238022.118
...Francisco, San Francisco, California 94158, USA; 3Chan-Zuckerberg Biohub, San Francisco, California 94158, USA Corresponding author: kpollard@gladstone.ucsf.eduAbstractChromatin interactions and
linkage
disequilibrium
(LD) are both pairwise measurements between genomic loci that show block patterns along...
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Research
:
Timescale and genetic linkage explain the variable impact of defense systems on horizontal gene transfer
Yang Liu
,
João Botelho
,
and
Jaime Iranzo
Genome Res.
February 2025
35
:
268
-
278
;
Published in Advance
January 10, 2025
,
doi:
10.1101/gr.279300.124
...). However, because MGEs are vehicles for the exchange of beneficial accessory genes, defense systems could consequently impede rapid adaptation in microbial
populations
. Here, we study how defense systems impact horizontal gene transfer (HGT) in the short term and long term. By combining comparative...
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Resource
:
Haplotype-resolved genome and population genomics of the threatened garden dormouse in Europe
Paige A. Byerly
,
Alina von Thaden
,
Evgeny Leushkin
,
Leon Hilgers
,
Shenglin Liu
,
Sven Winter
,
Tilman Schell
,
Charlotte Gerheim
,
Alexander Ben Hamadou
,
Carola Greve
,
Christian Betz
,
Hanno J. Bolz
,
Sven Büchner
,
Johannes Lang
,
Holger Meinig
,
Evax Marie Famira-Parcsetich
,
Sarah P. Stubbe
,
Alice Mouton
,
Sandro Bertolino
,
Goedele Verbeylen
,
Thomas Briner
,
Lídia Freixas
,
Lorenzo Vinciguerra
,
Sarah A. Mueller
,
Carsten Nowak
,
and
Michael Hiller
Genome Res.
November 2024
34
:
2094
-
2107
;
Published in Advance
November 14, 2024
,
doi:
10.1101/gr.279066.124
...samples with a mean per site depth of 14.75× and mean frequency of missingness of 0.11 (Supplemental Table S2). For analyses dependent on allele frequencies, such as principal component analysis (PCA)-based analyses, we pruned SNPs based on
linkage
disequilibrium
(LD), resulting in a data set of 19...
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Research
:
Worldwide patterns of genomic variation and admixture in gray wolves
Zhenxin Fan
,
Pedro Silva
,
Ilan Gronau
,
Shuoguo Wang
,
Aitor Serres Armero
,
Rena M. Schweizer
,
Oscar Ramirez
,
John Pollinger
,
Marco Galaverni
,
Diego Ortega Del-Vecchyo
,
Lianming Du
,
Wenping Zhang
,
Zhihe Zhang
,
Jinchuan Xing
,
Carles Vilà
,
Tomas Marques-Bonet
,
Raquel Godinho
,
Bisong Yue
,
and
Robert K. Wayne
Genome Res.
February 2016
26
:
163
-
173
;
Published in Advance
December 17, 2015
,
doi:
10.1101/gr.197517.115
...was performed using the pairwise allele-sharing genetic distance. Following vonHoldt et al. (2011), sites exhibiting apparent strong local
linkage
disequilibrium
(R2 > 0.5) were filtered using the –indep option in PLINK (–indep 50 5 0.2) (Purcell et al. 2007). To improve resolution among wolves, the two golden...
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Method
:
Diffusion-enhanced characterization of 3D chromatin structure reveals its linkage to gene regulatory networks and the interactome
Yueying He
,
Yue Xue
,
Jingyao Wang
,
Yupeng Huang
,
Lu Liu
,
Yanyi Huang
,
and
Yi Qin Gao
Genome Res.
August 2023
33
:
1354
-
1368
;
Published in Advance
July 25, 2023
,
doi:
10.1101/gr.277737.123
...is a painfully crowded and complex environment for proteins to find and associate with each other faithfully in a timely and well-organized manner, as required by signal transduction, especially if the
population
and distribution of individual proteins were entirely random or independent...
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Research
:
Comparative genomics of
Cryptosporidium parvum
reveals the emergence of an outbreak-associated population in Europe and its spread to the United States
Greta Bellinzona
,
Tiago Nardi
,
Michele Castelli
,
Gherard Batisti Biffignandi
,
Karim Adjou
,
Martha Betson
,
Yannick Blanchard
,
Ioana Bujila
,
Rachel Chalmers
,
Rebecca Davidson
,
Nicoletta D'Avino
,
Tuulia Enbom
,
Jacinto Gomes
,
Gregory Karadjian
,
Christian Klotz
,
Emma Östlund
,
Judith Plutzer
,
Ruska Rimhanen-Finne
,
Guy Robinson
,
Anna Rosa Sannella
,
Jacek Sroka
,
Christen Rune Stensvold
,
Karin Troell
,
Paolo Vatta
,
Barbora Zalewska
,
Claudio Bandi
,
Davide Sassera
,
and
Simone M. Cacciò
Genome Res.
June 2024
34
:
877
-
887
;
Published in Advance
July 8, 2024
,
doi:
10.1101/gr.278830.123
....Within-
population
genetic indicesTo gain further insight into the genetic differentiation of the two
populations
in the “Western” lineage (i.e.,
populations
2 and 3), we calculated
linkage
disequilibrium
(LD) decay, Tajima's D values, and nucleotide diversity (π).We found that
population
3 had a slower...
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Method
:
Leveraging family data to design Mendelian randomization that is provably robust to population stratification
Nathan LaPierre
,
Boyang Fu
,
Steven Turnbull
,
Eleazar Eskin
,
and
Sriram Sankararaman
Genome Res.
July 2023
33
:
1032
-
1041
;
Published in Advance
May 17, 2023
,
doi:
10.1101/gr.277664.123
...for standard MR methods (Supplemental Fig. S2). We observed inflated FPR for standard MR methods even when there is no confounding (stratification) for large values of FST (Supplemental Fig. S2) likely owing to correlation or
linkage
disequilibrium
(LD) among the genetic variants induced by
population
...
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Research
:
Human population dispersal “Out of Africa” estimated from linkage disequilibrium and allele frequencies of SNPs
Brian P. McEvoy
,
Joseph E. Powell
,
Michael E. Goddard
,
and
Peter M. Visscher
Genome Res.
June 2011
21
:
821
-
829
;
Published in Advance
April 25, 2011
,
doi:
10.1101/gr.119636.110
...Human
population
dispersal “Out of Africa” estimated from
linkage
disequilibrium
and allele frequencies of SNPs Brian P. McEvoy 1 , 4 , Joseph E. Powell 1 , 4 , 5 , Michael E. Goddard 2 , 3 and Peter M. Visscher 1 1Queensland...
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Methods
:
Recent human effective population size estimated from linkage disequilibrium
Albert Tenesa
,
Pau Navarro
,
Ben J. Hayes
,
David L. Duffy
,
Geraldine M. Clarke
,
Mike E. Goddard
,
and
Peter M. Visscher
Genome Res.
April 2007
17
:
520
-
526
;
Published in Advance
March 9, 2007
,
doi:
10.1101/gr.6023607
...Recent human effective
population
size estimated from
linkage
disequilibrium
Albert Tenesa 1 , 2 , 3 , Pau Navarro 3 , Ben J. Hayes 4 , David L. Duffy 5 , Geraldine M. Clarke 6 , Mike E. Goddard 4 , 7 , and Peter M...
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Single-cell gene signature scoring
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Short tandem repeat genotyping using long reads
Spectral component approach for recent population structure
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