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Perspective: Unraveling the hidden complexity of cancer through long-read sequencing
- Qiuhui Li,
- Ayse G. Keskus,
- Justin Wagner,
- Michal B. Izydorczyk,
- Winston Timp,
- Fritz J. Sedlazeck,
- Alison P. Klein,
- Justin M. Zook,
- Mikhail Kolmogorov,
- and Michael C. Schatz
Genome Res. April 2025 35: 599-620; Published in Advance March 20, 2025, doi:10.1101/gr.280041.124
...excluded from variant benchmarks even with near-perfect assemblies due to challenges in aligning, representing, and comparing large complex SVs around segmental duplications and satellite repeats.View larger version: In this window In a new window Figure 2. Comparative analysis of structural variation...
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Editorial: Long reads decipher genomes and transcriptomes and offer novel insights into biology and diseases
- Ana Conesa,
- Alexander Hoischen,
- and Fritz J. Sedlazeck
Genome Res. April 2025 35: xi-xiv; doi:10.1101/gr.280665.125
...-methyladenosine modifications. Genome Res (this issue) 35: 999–1011. doi:10.1101/gr.279270.124 ↵Paulin LF, Fan J, O'Neill K, Pleasance E, Porter VL, Jones SJM, Sedlazeck FJ. 2025. Closing the gaps, and improving somatic structural variant analysis and benchmarking using CHM13-T2T. Genome Res (this issue) 35: 621...

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