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  1. ...(Fig. 6E). These findings reveal that despite expected differences between xenografted cultured cells and primary tumors, our strategy identified relevant, tumor-specific accessible chromatin regions.View larger version: In this window In a new window Figure 6. Tumor-specific regions identified...
  2. ...cell proliferation downstream from the retinoblastoma tumor suppressor. Different E2F family members promote or suppress oncogenesis in a tissue- and tumor-dependent manner (Chen et al. 2009). Little is known about the interplay of tumor-specific oncoproteins with E2F transcription factors...
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