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Method: High-throughput single-cell functional elucidation of neurodevelopmental disease–associated genes reveals convergent mechanisms altering neuronal differentiation
- Matthew A. Lalli,
- Denis Avey,
- Joseph D. Dougherty,
- Jeffrey Milbrandt,
- and Robi D. Mitra
Genome Res. September 2020 30: 1317-1331; Published in Advance September 4, 2020, doi:10.1101/gr.262295.120
...characterized for its ability to differentiate into dopaminergic neurons, cell type–specific expression analysis (CSEA) of differentiated LUHMES revealed that these neurons have transcriptional profiles that are highly similar to a range of neuronal subtypes relevant to neurological disorders (Supplemental Fig...
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Review: The superpowers of imprinting control regions
- Bertille Montibus,
- Franck Court,
- and Philippe Arnaud
Genome Res. January 2026 36: 1-19; Published in Advance December 10, 2025, doi:10.1101/gr.281215.125
..., the molecular basis of finely controlled gene expression.The functional specialization of each cell type and tissue is a complex process in higher organisms. It depends on the cell's ability to establish its own transcriptional profile in response to developmental and environmental cues. This process involves...

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