Searching journal content for articles similar to Pace et al. 10 (9): 1414.

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  1. .... The candidates include genes encoding for secreted proteins, such as ankyrin repeat-containing proteins, which have been shown in Toxoplasma to be involved in cell invasion (Long et al. 2017), and a RING/Armadillo-type fold domain–containing protein that in Plasmodium falciparum mediates the motility...
  2. ...; Vembar et al. 2016). Evidence for post-transcriptional regulation in Plasmodium spp. includes several studies that have reported a significant delay 3Present address: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK Corresponding author: manuel@psu.edu Article...
  3. ...Malaria genetic variation has been extensively characterized, but the level of epigenetic plasticity remains largely unexplored. Here we provide a comprehensive characterization of transcriptional variation in the most lethal malaria parasite, Plasmodium falciparum, based on highly accurate transcriptional...
  4. ...to increased virulence in C. albicans. Exceptions to genomic colinearity concern genes with known associations to pathogenesis. While the C. dubliniensis and C. albicans s largely correspond, there are various inversion, insertion–deletion, and transposition events that disrupt the otherwise collinear gene...
  5. ...—with their richer metabolism and transport—is easier to evolve than development in enucleated mammalian erythrocytes, it is tempting to speculate that these parasites more closely resemble the ancestral state.In this study, we describe the sequence, annotation, and comparative genomics of Plasmodium relictum SGS1...
  6. ...Supplemental Materials for details). Additionally, GRIDSS identified genomic breakpoints associated with a further three of the validated fusion genes.Application to Plasmodium falciparum dataTo test the behavior of GRIDSS on a challenging AT-rich nonmammalian , it was applied to a laboratory strain...
  7. ...of expression clones encoding Plasmodium falciparum single-exon genes. Master clones and their ORFs were transferred en masse to multiple expression vectors. Target genes ( n = 303) were selected using specific sets of criteria, including stage expression and secondary structure. Upon screening four colonies...
  8. ...of sequence sampled from the remainder of the genome. To construct a robust physical map, we devised a novel and general strategy, enabling accurate placement of clones regardless of clone artefacts. Analysis reveals a compact genome, unusually rich in membrane proteins. As in Plasmodium falciparum...
  9. ...of Plasmodium falciparum parasites to available drugs. Proteases are attractive antimalarial targets because of their indispensable roles in parasite infection and development, especially in the processes of host erythrocyte rupture/invasion and hemoglobin degradation. However, to date, only a small number...
  10. ....27–1.55 Mya) (Supplemental Fig. S3B), after the three allelic lineages of 3DL1/S1 split. As the Igdomain divergence preceded the genomic deletion event, 3DL1/2v arose at a time potentially close to the emergence of modern humans (;200,000 yr ago) (Relethford 2008). Lastly, our finding that all three variants...
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