Searching journal content for articles similar to Orsi et al. 24 (5): 809.

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  1. Research: Polycomb misregulation in enterocytes drives tissue decline in the aging Drosophila intestine
    • Sarah M. Leichter,
    • Kami Ahmad,
    • and Steven Henikoff
    Genome Res. January 2026 36: 102-114; Published in Advance November 17, 2025, doi:10.1101/gr.281058.125
    ...that aging not only weakens pre-existing Polycomb domains but also establishes new repressive marks in differentiated intestinal cells, reshaping the chromatin landscape in a cell type–specific manner.Changes in repression at regulatory elements with ageA major advantage of sciCUT&Tag is the ability...
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  2. Research: Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes
    • Hamish W. King,
    • Nadezda A. Fursova,
    • Neil P. Blackledge,
    • and Robert J. Klose
    Genome Res. October 2018 28: 1494-1507; Published in Advance August 28, 2018, doi:10.1101/gr.237180.118
    ..., and accessibility is often related to post-translational modification of histones associated with gene regulatory elements. By extension, it has been proposed that chromatin-modifying systems and their associated activities may help to define accessibility at these important regulatory sites.In animals, Polycomb...
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  3. Letter: High-resolution analysis of epigenetic changes associated with X inactivation
    • Hendrik Marks,
    • Jennifer C. Chow,
    • Sergei Denissov,
    • Kees-Jan Françoijs,
    • Neil Brockdorff,
    • Edith Heard,
    • and Hendrik G. Stunnenberg
    Genome Res. August 2009 19: 1361-1373; Published in Advance July 6, 2009, doi:10.1101/gr.092643.109
    ...al. 2004; Okamoto et al. 2004), which are associated with heterochromatin and silencing. Among these, H3K27me3 has been studiedmost extensively. The Polycomb group repressive complex 2 (PRC2), and in particular its enzymatic component Ezh2, appears to be responsible for the deposition of this mark...
  4. Research: High resolution mapping of Twist to DNA in Drosophila embryos: Efficient functional analysis and evolutionary conservation
    • Anil Ozdemir,
    • Katherine I. Fisher-Aylor,
    • Shirley Pepke,
    • Manoj Samanta,
    • Leslie Dunipace,
    • Kenneth McCue,
    • Lucy Zeng,
    • Nobuo Ogawa,
    • Barbara J. Wold,
    • and Angelike Stathopoulos
    Genome Res. April 2011 21: 566-577; Published in Advance March 7, 2011, doi:10.1101/gr.104018.109
    ...these regions as potentially ‘‘open chromatin’’, as these same motifs were recently found associated with DNA occupied by Trithorax and Polycomb group/recruitment factors (see Schuettengruber and Cavalli 2009; and Discussion). Interactions between Twist and other transcription factors might exist, yet...
  5. Research: The chromatin environment shapes DNA replication origin organization and defines origin classes
    • Christelle Cayrou,
    • Benoit Ballester,
    • Isabelle Peiffer,
    • Romain Fenouil,
    • Philippe Coulombe,
    • Jean-Christophe Andrau,
    • Jacques van Helden,
    • and Marcel Méchali
    Genome Res. December 2015 25: 1873-1885; Published in Advance November 11, 2015, doi:10.1101/gr.192799.115
    ...are mainly found in this class. Class 2 origins are particularly rich in enhancer elements. Class 3 origins are the most efficient and are associated with open chromatin and polycomb protein-enriched regions. The presence of Origin G-rich Repeated elements (OGRE) potentially forming G-quadruplexes (G4...
  6. Research: Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations
    • Stefan F. Pinter,
    • Ruslan I. Sadreyev,
    • Eda Yildirim,
    • Yesu Jeon,
    • Toshiro K. Ohsumi,
    • Mark Borowsky,
    • and Jeannie T. Lee
    Genome Res. October 2012 22: 1864-1876; Published in Advance September 4, 2012, doi:10.1101/gr.133751.111
    ...elements on ChrX and provided a first hint of how Polycomb silencing may be propagated from the Xic. An open question is how Xi spreading elements relate to Polycomb response elements (PRE), which remain poorly defined in mammals (Simon and Kingston 2009). Also unknown is how bivalent and noncanonical...
  7. Research: Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer
    • Phillippa C. Taberlay,
    • Aaron L. Statham,
    • Theresa K. Kelly,
    • Susan J. Clark,
    • and Peter A. Jones
    Genome Res. September 2014 24: 1421-1432; Published in Advance June 10, 2014, doi:10.1101/gr.163485.113
    ..., and are commonly paired with promoters that are repressed by the Polycomb repressive complex in order to facilitate cellular reprogramming by master regulatory factors (Taberlay et al. 2011). In contrast, we found that cancer cells are rendered resistant to cellular reprogramming if the cognate enhancer...
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  8. Research: NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors
    • Joseph D. Fleming,
    • Giulio Pavesi,
    • Paolo Benatti,
    • Carol Imbriano,
    • Roberto Mantovani,
    • and Kevin Struhl
    Genome Res. August 2013 23: 1195-1209; Published in Advance April 17, 2013, doi:10.1101/gr.148080.112
    ...to active coding regions. Although lesswell defined, other DNA-binding proteins and nascent RNA can recruit H3K27 or H3K9 methylases to other genomic regions, resulting in heterochromatic silencing by polycomb complexes (PcG) or HP1, respectively. As a consequence of the above and other mechanistic...
  9. Review: The superpowers of imprinting control regions
    • Bertille Montibus,
    • Franck Court,
    • and Philippe Arnaud
    Genome Res. January 2026 36: 1-19; Published in Advance December 10, 2025, doi:10.1101/gr.281215.125
    ...and functional studies have highlighted the critical roles of Polycomb repressive complexes 1 and 2 (PRC1 and PRC2), which catalyze the deposition of H2AK119ub1 and H3K27me3, respectively, as well as the methyltransferase EHMT2, which deposits H3K9me2, in this silencing mechanism (Fig. 4; Mager et al. 2003...
  10. Resource: Epigenomics of embryogenesis in turbot
    • Oscar Aramburu,
    • Belen G Pardo,
    • Ada Jimenez-Gonzalez,
    • Andrés Blanco-Hortas,
    • Daniel Macqueen,
    • Carmen Bouza,
    • and Paulino Martinez
    Genome Res. November 4, 2025 gr.280355.124; Published in Advance November 4, 2025, doi:10.1101/gr.280355.124
    ...established (Minnoye et al., 2021). Our 10-state chromatin model defined states 529 associated with active promoters and enhancers, repressed Polycomb regions 530 and ATAC islands, annotated in other species following the same approach 531 (Heintzman et al., 2007; Barral and Déjardin, 2023). Two...
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