Searching journal content for articles similar to Olson and Green 8 (5): 414.

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  1. ...would expect all genes to have homologs. Since the first sequencing projects, researchers have been struck by the occurrence in almost every of “ORFan” genes, those that lack homologs outside of the taxon in which they are found. Numerous explanations have been provided for the existence of ORFans (aka...
  2. ...Sophia N. Lee1, Erin C. Banda2,5, Lu Qiao1,5, Sarah L. Thompson1, Karan Singh3, Ryan A. Hagenson1, Teresa Davoli3, Stefan F. Pinter2,4 and Jason M. Sheltzer1 1Yale University School of Medicine, New Haven, Connecticut 06510, USA; 2Department of Genetics and Genome Sciences, UCONN Health, University...
  3. ...David R. Lougheed1,2, Tomi Pastinen3 and Guillaume Bourque1,2,4 1Canadian Centre for Computational Genomics, Montréal, Québec H3A 0G1, Canada; 2Department of Human Genetics, McGill University, Montréal, Québec H3A 0G1, Canada; 3Genomic Medicine Center, Children's Mercy Hospital and Research...
  4. ...Ruhollah Shemirani1, Gillian M. Belbin1,9, Sinead Cullina1,2, Christa Caggiano1, Christopher R. Gignoux3,4, Noah Zaitlen5,6,7 and Eimear E. Kenny1,2,8 1Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA; 2Department of Genetics and Genomic Sciences...
  5. ...Pan analysis reveals families of ubiquitin-ligase adaptors as key genomic divergence drivers that lead to hybrid incompatibility Dongying Xie1,2,3, Pohao Ye1,3, Yiming Ma1 and Zhongying Zhao1 1Department of Biology, Hong Kong Baptist University, Hong Kong SAR, China; 2Institute for Research...
  6. ...for genomic data. Integrated into diverse architectures such as convoluted neural networks (CNNs), long short-term memory (LSTM), dilated CNNs, and transformers, ConvNeXt V2 blocks consistently improve performance, leading to similar prediction accuracy across these different model types. This reveals...
  7. ...diffusion for affinity-based transition embedding (PHATE) (Moon et al. 2019), a dimensionality reduction method that preserves both local and global structure in the data, to project analyzed cells into a low-dimensional manifold. The resulting ANS score–based embeddings accurately reconstructed...
  8. ...) + 21 (ONT R10).We evaluated the quality of all WGS data set and confirmed that all 76 samples met high-quality standards (Supplemental Tables S1, S3). These thresholds were defined based on the UK Biobank (Sudlow et al. 2015), The 1000 Genomes Project (1000 Genomes Project Consortium et al. 2015...
  9. ....pantalacci@ens-lyon.fr, marie.semon@ens-lyon.frAbstractSpecies adapting to a similar lifestyle may undergo convergent changes in organ structure and cellular function, themselves relying or not on these convergent genetic changes. The extent of genomic convergence is thus debated and may further depend on the interplay between...
  10. ...Cell type–specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease Yunxiao Ren1,2, Ming Hu3,4, Yang E. Li5, Andrew A. Pieper6,7,8,9,10,11, Jeffrey Cummings12 and Feixiong Cheng1,2,4,13 1Cleveland Clinic Genome Center, Cleveland Clinic Research...
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