Searching journal content for articles similar to O'Keefe and Matera 10 (9): 1342.

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  1. ...-replicating DNA compared with CySC-like cells (Fig. 4E). These differences span substantial portions of the . For example, earlier-replicating domains in GSC-like cells account for 60% of the pericentromeric heterochromatin on Chromosome 2. A notable exception is the Y Chromosome, in which 9% of the Y Chromosome...
  2. ...that the centromeric alpha satellite has an intrinsic tendency to form secondary structures, including hairpins, but also that the binding of the CENPB protein to the satellite repeats promotes formation of submicron-sized DNA loops important for centromere stability and its positioning (Chardon et al. 2022...
  3. ...the missegregation of a specific chromosome. (B) Copy numbers of CSMD1, MICU3, and CRISPLD1 (a gene located on the q arm of Chromosome 8), in trisomic proband clones that were transiently transfected with KaryoCreate plasmids. Mean ± SEM; data from representative trials are shown (n ≥ 3 total trials). Genomic DNA...
  4. ...of abundant euchromatic satDNAs. Unexpectedly, we show the extensive spread of satDNAs in gene-rich regions, including long arrays. The sequence similarity relationships between satDNA monomers and arrays indicate a recent exchange of satDNA arrays between different chromosomes. We propose a scenario...
  5. ...24 0 to 8 hours) integrates over 250 paired transcriptome and proteome measurements. We 25 observe upregulation of known DNA repair proteins as well as a global dynamic response of 26 not yet characterized transcripts and proteins. Using artificial neural networks, we classify 27 different expression...
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  6. ...satellite arrays. In some species, SatDNA may be organized as high-order repeats (HORs; Miga 2019 ). For example, the centromere of human Chromosome 2 has a pattern like “ABCDABCDABCD⋯”. Letters “A”–“D” correspond to four diverged alpha repeat monomers of ∼171 bp each, respectively, and the “ABCD” unit...
  7. ...to segregate chromosomes, are typically found within satellite arrays in plants and animals. Satellite arrays have been difficult to analyze because they comprise megabases of tandem head-to-tail highly repeated DNA sequences. Much evidence suggests that centromeres are epigenetically defined by the location...
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  8. ...the advantage of the PacBio HiFi reads in assembly of highly repetitive s. To investigate the quality, we also quantified the satellite DNA distribution along each chromosome (Supplemental Fig. S1). The most dominant satellites are LmiSat02A-176 and LmiSat27A-57. In addition, we identified several centromere...
  9. ...of highly repetitive DNA, such as long stretches of simple repeats, or structural mosaicism within the same cell line. However, neither possibility would impact the conclusions of the present study.SUNK estimates of paralogous genes within copy-number variant segments do not always align with expectations...
  10. ...probabilities of six different ML algorithms. Liu et al. (2022) addressed a sample imbalance of species via scale-aware learning, integrating class weights into cross-entropy loss to develop MSNet-4mC. Based on Hyb4mC (Liang et al. 2022), iDNA-MS (Lv et al. 2020), and DeepTorrent (Liu et al. 2021a), Li et al...
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