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  1. ..., Tesler G, Auvil L, Beever JE, Chowdhary BP, Galibert F, Gatzke L, et al. 2005. Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps. Science 309: 613–617. Niimura Y, Nei M. 2007. Extensive gains and losses of olfactory receptor genes in mammalian evolution. PLoS ONE 2: e...
  2. ...sequence, and one is immediately adjacent to orthologous sequence that is ampliconic in human (∼135 Mb), although the cat sequence is not ampliconic (Supplemental Table S4). One of these novel genes encodes a putative olfactory receptor (98% similarity to an annotated cheetah gene), and a second shares 91...
  3. ...of phenotypic evolution. Nat Rev Genet 14: 645–660. ↵Chess A. 2005. Monoallelic expression of protocadherin genes. Nat Genet 37: 120–121. ↵Clowney EJ, Magklara A, Colquitt BM, Pathak N, Lane RP, Lomvardas S. 2011. High-throughput mapping of the promoters of the mouse olfactory receptor genes reveals a new type...
  4. .... Hum. Mol. Genet. 11 : 1987 –1995. ↵ Giglio, S., Broman, K.W., Matsumoto, N., Calvari, V., Gimelli, G., Neumann, T., Ohashi, H., Voullaire, L., Larizza, D., Giorda, R., et al. 2001 . Olfactory receptor-gene clusters, genomic-inversion polymorphisms, and common chromosome rearrangements. Am. J. Hum...
  5. ...in inversions during primate evolution; 10 were reused by breaks during mammalian evolution; 14 showed copy number polymorphism in man. TBSD sites showed an increase in satellite repeats, retrotransposed sequences, and other segmental duplications. We propose that the instability of these sites stems from...
  6. ....7%–2.0% of the is predicted to be duplicated by our analyses ( Table 5 ). We assessed protein domain assignments associated with each of these RefSeq genes (Methods). As in human, genes involved in immunity/defense (defensins, serpins, immunoglobulin containing proteins) and growth/development (B56 and hormone receptor...
  7. ...(Supplemental Table S8); these include genes belonging to several groups, including members involved in the response to bacteria, genes with chemokine receptor binding activity, and golgin family members (Supplemental Table S9). At least five of the inversions that were validated by PCR overlap genes, with two...
  8. .... Here, we report a large-scale study of the expression evolution of DNA-based functional gene duplicates in three major mammalian lineages (placental mammals, marsupials, egg-laying monotremes) and birds, on the basis of RNA sequencing (RNA-seq) data from nine species and eight organs. We observe...
  9. ...@mail.ecc.u-tokyo.ac.jp Abstract Olfactory receptors (ORs) detect odors in the environment, and OR genes constitute the largest multigene family in mammals. Numbers of OR genes vary greatly among species—reflecting the respective species' lifestyles—and this variation is caused by frequent gene gains and losses during evolution...
  10. ...adaptations was evident from positively selected genes involving immunity-related pathways, inflammation, energy storage and metabolism, muscular and nervous systems, and scale/hair development. Olfactory receptor gene families are significantly expanded in pangolins, reflecting their well-developed olfaction...
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