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  1. ...the consequences of the deletion on regional control of gene expression and imprinting.ResultsLarge L1 arrays are associated with tandem gene clusters in the mammalian To determine where in the mouse stretches of dense LINE content reside, regions containing >70% LINEs of >100 kb length were cataloged. Sixty...
  2. ...of high conservation among all species indicates that the most conserved regions are exons of genes (Fig. 3B). There is also a high level of conservation over the exons of the XIST locus (Fig. 3B). There are small peaks of conservation outside of coding regions, themajority of which are unique sequences...
  3. ..., including the Xist gene. These comparisons have revealed conserved genes, both coding and noncoding, conserved CpG islands and, more surprisingly, conserved pseudogenes. The distribution of repeated elements, especially LINE repeats, in the mouse Xic region when compared to the rest of the genome does...
  4. ....I., Johnston, C., Pavlova, M.E., Rogozin, I.B., Kolesnikov, N.N., Brockdorff, N., and Zakian, S.M. 2001 . Characterization of the genomic Xist locus in rodents reveals conservation of overall gene structure and tandem repeats but rapid evolution of unique sequence. Genome Res. 11 : 833 -849. ↵ Okazaki, Y...
  5. ...have significantly conserved sequences (Panga et al. 2006). For example, the XIST ncRNA has a clear function in X chromosome inactivation in mammals (Kelley and Kuroda 2000); however, a comparison of human and mouse XIST reveals a low overall sequence identity (Nesterova et al. 2001). While our...
  6. ...). Innovation and rapid evolution is also evident in thousands of gene regulatory sequences, which cover extended genomic regions and exhibit rapid turnover ( Smith et al. 2004 ; Fisher et al. 2006 ; Frith et al. 2006 ; Taylor et al. 2006 ). This includes the remarkable functional conservation of regulatory...
  7. ...). Furthermore, the large noncoding RNA, XIST, is essential for sex chromosome dosage compensation in mammals, and yet exhibits rapid evolution of primary sequences despite an overall conservation of gene structure and organization ( Nesterova et al. 2001 ). Third, noncoding transcripts may adopt secondary...
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