Searching journal content for articles similar to Nergadze et al. 14 (9): 1704.

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  1. Review: The structure, function, and evolution of plant centromeres
    • Matthew Naish and
    • Ian R. Henderson
    Genome Res. February 2024 34: 161-178; Published in Advance March 14, 2024, doi:10.1101/gr.278409.123
    ...crossover could contribute to centromere evolution (Smith 1976). In this influential model, meiotic DNA double-strand breaks (DSBs) are repaired using a nonallelic location on a homolog, with the potential to cause gain and loss of intervening tandem repeats (Smith 1976). However, it is widely documented...
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  2. LETTER: A preliminary comparative analysis of primate segmental duplications shows elevated substitution rates and a great-ape expansion of intrachromosomal duplications
    • Xinwei She,
    • Ge Liu,
    • Mario Ventura,
    • Shaying Zhao,
    • Doriana Misceo,
    • Roberta Roberto,
    • Maria Francesca Cardone,
    • Mariano Rocchi,
    • NISC Comparative Sequencing Program,
    • Eric D. Green,
    • Nicoletta Archidiacano,
    • and Evan E. Eichler
    Genome Res. May 2006 16: 576-583; Published in Advance April 10, 2006, doi:10.1101/gr.4949406
    .... ( 2003 ) Enrichment of segmental duplications in regions of breaks of synteny between the human and mouse s suggest their involvement in evolutionary rearrangements. Hum. Mol. Genet. 12 : 2201 – 2208 . ↵ Bailey J.A. , Yavor A.M. , Massa H.F. , Trask B.J. , Eichler E.E. ( 2001 ) Segmental duplications...
  3. ARTICLE: Serial segmental duplications during primate evolution result in complex human genome architecture
    • Paweł Stankiewicz,
    • Christine J. Shaw,
    • Marjorie Withers,
    • Ken Inoue,
    • and James R. Lupski
    Genome Res. November 2004 14: 2209-2220; doi:10.1101/gr.2746604
    ...of segmental duplications in regions of breaks of synteny, suggesting their involvement in evolutionary rearrangements ( Probst et al. 1999 ; Bi et al. 2002 ; Armengol et al. 2003 ; Kent et al. 2003 ; Pennacchio 2003 ; Pevzner and Tesler 2003 ). Recently, however, Bailey et al. ( 2004 ) proposed...
  4. LETTER: Evidence for a Fast, Intrachromosomal Conversion Mechanism From Mapping of Nucleotide Variants Within a Homogeneous α-Satellite DNA Array
    • Dirk Schindelhauer and
    • Tobias Schwarz
    Genome Res. December 1, 2002 12: 1815-1826; doi:10.1101/gr.451502
    ...the double-strand-break repair pathway ( Szostak et al. 1983 ; for review on recombination, see Bollag et al. 1989 ) in human cells if divergence exceeds a few percent ( Taghian and Nickoloff 1997 ; Elliott et al. 1998 ; Johnson and Jasin 2000 ). To exclude patches of abnormal homology within PAC A7, we...
  5. LETTER: Segmental duplications and evolutionary plasticity at tumor chromosome break-prone regions
    • Eva Darai-Ramqvist,
    • Agneta Sandlund,
    • Stefan Müller,
    • George Klein,
    • Stefan Imreh,
    • and Maria Kost-Alimova
    Genome Res. March 2008 18: 370-379; Published in Advance January 29, 2008, doi:10.1101/gr.7010208
    ...in inversions during primate evolution; 10 were reused by breaks during mammalian evolution; 14 showed copy number polymorphism in man. TBSD sites showed an increase in satellite repeats, retrotransposed sequences, and other segmental duplications. We propose that the instability of these sites stems from...
  6. REVIEW: The biological effects of simple tandem repeats: Lessons from the repeat expansion diseases
    • Karen Usdin
    Genome Res. July 2008 18: 1011-1019; doi:10.1101/gr.070409.107
    .... 2006 ). Since these proteins are key components of the cellular response to stalled replication forks, it supports the idea that fragile sites block or retard the progress of the DNA replication machinery. Common fragile sites may represent double-strand breaks formed because of stalled replication...
  7. ARTICLE: Complex Evolution of 7E Olfactory Receptor Genes in Segmental Duplications
    • Tera Newman and
    • Barbara J. Trask
    Genome Res. May 1, 2003 13: 781-793; doi:10.1101/gr.769003
    ...beneficial function. Moreover, there is evidence that 7E SDs can be disadvantageous, as they can mediate harmful genomic rearrangements ( Giglio et al. 2001 , 2002 ). So far, 7E SDs have been found at the break-points of multiple large intrachromosomal rearrangements of 8p causing mental handicap...
  8. LETTER: Gene conversion and evolution of Xq28 duplicons involved in recurring inversions causing severe hemophilia A
    • Richard D. Bagnall,
    • Karen L. Ayres,
    • Peter M. Green,
    • and Francesco Giannelli
    Genome Res. February 2005 15: 214-223; doi:10.1101/gr.2946205
    ...and cosegregation of the duplicated regions favors retention of the ancestral sequence and thus reduces the evolution rate. One in 30,000 males is born with an inversion breaking the factor VIII gene ( F8 ) and causing severe hemophilia A. In 90% of these patients the break is in intron 22 of F8 and affects a 9...
  9. LETTER: Genomic Structure and Evolution of the Ancestral Chromosome Fusion Site in 2q13–2q14.1 and Paralogous Regions on Other Human Chromosomes
    • Yuxin Fan,
    • Elena Linardopoulou,
    • Cynthia Friedman,
    • Eleanor Williams,
    • and Barbara J. Trask
    Genome Res. November 1, 2002 12: 1651-1662; doi:10.1101/gr.337602
    ....e., 2qFus-Dist and 2qFus-Prox are the regions forming the distal and proximal sides of the 2q fusion site, respectively; both were at chromosome tips when the duplicative transfers occurred). Ancestral and derived states, when indicated, are inferred from breaks that disrupt genes, specific repetitive...
  10. Research: Interchromosomal core duplicons drive both evolutionary instability and disease susceptibility of the Chromosome 8p23.1 region
    • Kiana Mohajeri,
    • Stuart Cantsilieris,
    • John Huddleston,
    • Bradley J. Nelson,
    • Bradley P. Coe,
    • Catarina D. Campbell,
    • Carl Baker,
    • Lana Harshman,
    • Katherine M. Munson,
    • Zev N. Kronenberg,
    • Milinn Kremitzki,
    • Archana Raja,
    • Claudia Rita Catacchio,
    • Tina A. Graves,
    • Richard K. Wilson,
    • Mario Ventura,
    • and Evan E. Eichler
    Genome Res. November 2016 26: 1453-1467; Published in Advance October 7, 2016, doi:10.1101/gr.211284.116
    ...of the duplication block and the midpoint of the closest inversion breakpoint. As expected, the observed association between IAR duplication blocks and inversion breakpoints is significant (P = 1 × 10−6). Since SDs have previously been shown to be associated with evolutionary rearrangements (91% of inversion breaks...
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