Searching journal content for articles similar to Naqvi et al. 28 (4): 474.

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  1. Research: Quantitative analysis of Y-Chromosome gene expression across 36 human tissues
    • Alexander K. Godfrey,
    • Sahin Naqvi,
    • Lukáš Chmátal,
    • Joel M. Chick,
    • Richard N. Mitchell,
    • Steven P. Gygi,
    • Helen Skaletsky,
    • and David C. Page
    Genome Res. June 2020 30: 860-873; Published in Advance May 27, 2020, doi:10.1101/gr.261248.120
    ...their expression likely remain intact and under considerable evolutionary constraint, despite millions of years of Y-Chromosome decay in the absence of regular recombination with the X Chromosome.Evolutionary loss of a microRNA target site promoted elevated EIF1AY expression in the heartWe also found evidence...
  2. Research: Dosage-sensitive functions in embryonic development drove the survival of genes on sex-specific chromosomes in snakes, birds, and mammals
    • Daniel W. Bellott and
    • David C. Page
    Genome Res. February 2021 31: 198-210; Published in Advance January 21, 2021, doi:10.1101/gr.268516.120
    ...of duplication (Fig. 2C). MicroRNAs (miRNAs) are short, noncoding RNAs that fine-tune gene dosage by pairing to the 3′ untranslated region and lowering target mRNA levels (Bartel 2009). Conserved targeting by miRNAs is a feature of genes sensitive to changes in gene dosage, particularly to overexpression (Naqvi...
  3. Research: Post-transcriptional cross- and auto-regulation buffer expression of the human RNA helicases DDX3X and DDX3Y
    • Shruthi Rengarajan,
    • Jason Derks,
    • Daniel W. Bellott,
    • Nikolai Slavov,
    • and David C. Page
    Genome Res. January 2025 35: 20-30; Published in Advance January 10, 2025, doi:10.1101/gr.279707.124
    ...-wise metrics of constraint on overexpression or loss of function: (1) PCT scores, which measure the evolutionary conservation of microRNA targeting sites in a gene's 3′ UTR (Friedman et al. 2009), and (2) LOEUF values, the ratio of observed to expected loss-of-function variants in a gene in human populations...
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