Searching journal content for articles similar to Nagarajan et al. 24 (5): 761.

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  1. Research: Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters
    • Shrutii Sarda,
    • Avinash Das,
    • Charles Vinson,
    • and Sridhar Hannenhalli
    Genome Res. April 2017 27: 553-566; Published in Advance February 21, 2017, doi:10.1101/gr.212050.116
    ...initiation at the upstream CGI and a lack thereof at the methylated proximal promoter itself. Consistent with their alternative promoter activity, CGI-initiated transcripts are associated with signals of stable elongation and splicing that extend into the gene body, as evidenced by tissue-specific RNA...
  2. Research: Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency
    • Linghua Wang,
    • Shuichi Tsutsumi,
    • Tokuichi Kawaguchi,
    • Koichi Nagasaki,
    • Kenji Tatsuno,
    • Shogo Yamamoto,
    • Fei Sang,
    • Kohtaro Sonoda,
    • Minoru Sugawara,
    • Akio Saiura,
    • Seiko Hirono,
    • Hiroki Yamaue,
    • Yoshio Miki,
    • Minoru Isomura,
    • Yasushi Totoki,
    • Genta Nagae,
    • Takayuki Isagawa,
    • Hiroki Ueda,
    • Satsuki Murayama-Hosokawa,
    • Tatsuhiro Shibata,
    • Hiromi Sakamoto,
    • Yae Kanai,
    • Atsushi Kaneda,
    • Tetsuo Noda,
    • and Hiroyuki Aburatani
    Genome Res. February 2012 22: 208-219; Published in Advance December 7, 2011, doi:10.1101/gr.123109.111
    ...to a mean coverage of 56-fold. This study identified a total of 1517 somatic mutations and validated 934 mutations by transcriptome sequencing. We detected recurrent mutations in 56 genes. Among them, 41 have not been described. The mutation rates varied widely among cell lines. The diversity...
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