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Review: Contrasting genetic architectures in different mouse reference populations used for studying complex traits
- David A. Buchner and
- Joseph H. Nadeau
Genome Res. June 2015 25: 775-791; Published in Advance May 7, 2015, doi:10.1101/gr.187450.114
...Research Institute, Seattle, Washington 98122, USA Quantitative trait loci (QTLs) are being used to study genetic networks, protein functions, and systems properties that underlie phenotypic variation and disease risk in humans, model organisms, agricultural species, and natural populations. The challenges...
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Research: Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver
- Xia Yang,
- Bin Zhang,
- Cliona Molony,
- Eugene Chudin,
- Ke Hao,
- Jun Zhu,
- Andrea Gaedigk,
- Christine Suver,
- Hua Zhong,
- J. Steven Leeder,
- F. Peter Guengerich,
- Stephen C. Strom,
- Erin Schuetz,
- Thomas H. Rushmore,
- Roger G. Ulrich,
- J. Greg Slatter,
- Eric E. Schadt,
- Andrew Kasarskis,
- and Pek Yee Lum
Genome Res. August 2010 20: 1020-1036; Published in Advance June 10, 2010, doi:10.1101/gr.103341.109
...to the response or adverse effects of various drugs used in the treatment of cancer, psychiatric disorders, and cardiovascular diseases (Anderson et al. 2003; van Schaik 2005; Vandel et al. 2007; Mega et al. 2009; Simon et al. 2009). In addition to genetic polymorphisms within P450 genes, regulatory mechanisms...
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