Searching journal content for articles similar to Mulder et al. 26 (2): 271.

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Research: Mapping multitissue regulatory variants reveals a liver-centric coexpression network associated with duck egg-laying performance
- Yang Xi,
- Jingjing Qi,
- Zhao Yang,
- Yutian Zeng,
- Huicong Zhang,
- Qiuyu Tao,
- Mengru Xu,
- Anqi Huang,
- Shenqiang Hu,
- Chunchun Han,
- Lili Bai,
- Jiwei Hu,
- Jiwen Wang,
- Liang Li,
- Lingzhao Fang,
- and Hehe Liu
Genome Res. October 2025 35: 2211-2225; Published in Advance September 10, 2025, doi:10.1101/gr.280345.124
..., interacting physiological systems. An increasing number of studies indicate that, beyond the traditionally emphasized hypothalamic–pituitary–gonadal (HPG) axis, metabolic and immune tissues are integral components of the regulatory network controlling laying performance. For instance, the liver sustains high...
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Research: Developmental transcriptomics in Pristionchus reveals the environmental responsiveness of a plasticity gene-regulatory network
- Shelley Reich,
- Tobias Loschko,
- Julie Jung,
- Samantha Nestel,
- Ralf J. Sommer,
- and Michael S. Werner
Genome Res. July 2025 35: 1560-1573; Published in Advance June 9, 2025, doi:10.1101/gr.279783.124
...expectations for when differential gene expression should matter. Here, we collated existing data into a gene-regulatory network (GRN) and performed developmental transcriptomics across different environmental conditions, genetic backgrounds, and mutants to assess the regulatory logic of mouth-form plasticity...
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Method: A new framework for exploratory network mediator analysis in omics data
- Qingpo Cai,
- Yinghao Fu,
- Cheng Lyu,
- Zihe Wang,
- Shun Rao,
- Jessica A. Alvarez,
- Yun Bai,
- Jian Kang,
- and Tianwei Yu
Genome Res. April 2024 34: 642-654; Published in Advance May 7, 2024, doi:10.1101/gr.278684.123
...Qingpo Cai1,6, Yinghao Fu2,3,6, Cheng Lyu1,6, Zihe Wang2, Shun Rao2, Jessica A. Alvarez4, Yun Bai3, Jian Kang5 and Tianwei Yu2 1Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322, USA; 2Shenzhen Research Institute of Big Data, School of Data Science...
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Method: A gene regulatory network–aware graph learning method for cell identity annotation in single-cell RNA-seq data
- Mengyuan Zhao,
- Jiawei Li,
- Xiaoyi Liu,
- Ke Ma,
- Jijun Tang,
- and Fei Guo
Genome Res. July 2024 34: 1036-1051; Published in Advance August 12, 2024, doi:10.1101/gr.278439.123
...; Zhang et al. 2019; Cheng and Ma 2022; Yu et al. 2022; Zhai et al. 2023). Additionally, some researchers are using a well-annotated cell atlas as a reference and constructing cell communication networks by assessing expression similarities. This helps transfer labels to newly sequenced data sets...
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Resource: Multiscale network modeling reveals the gene regulatory landscape driving cancer prognosis in 32 cancer types
- Peng Xu and
- Bin Zhang
Genome Res. October 2023 33: 1806-1817; Published in Advance October 31, 2023, doi:10.1101/gr.278063.123
....zhang@mssm.eduAbstractCancer is a complex disease with diverse molecular mechanisms that affect patient prognosis. Network-based approaches are effective in revealing a holistic picture of cancer prognosis and gene interactions. However, a comprehensive landscape of coexpression networks and prognostic gene modules across multiple cancer...
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Research: tRNA-derived small RNAs are embedded in the gene regulatory network instructing Drosophila metamorphosis
- Junling Shi,
- Jiaqi Xu,
- Jun Ma,
- and Feng He
Genome Res. December 2023 33: 2119-2132; Published in Advance November 16, 2023, doi:10.1101/gr.278128.123
...are tightly controlled, raising the possibility that their breakdown products, tsRNAs, may provide a link between the overall translational status of a cell to specific changes in gene regulatory network. We hypothesize that Drosophila pupation, being a special developmental stage during which...
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Method: Dissecting and improving gene regulatory network inference using single-cell transcriptome data
- Lingfeng Xue,
- Yan Wu,
- and Yihan Lin
Genome Res. September 2023 33: 1609-1621; Published in Advance August 14, 2023, doi:10.1101/gr.277488.122
..., 100871; 3Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, 100871 Corresponding author: yihan.lin@pku.edu.cnAbstractSingle-cell transcriptome data has been widely used to reconstruct gene regulatory networks (GRNs) controlling...
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Research: Histone deacetylases maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and noncoding loci
- Richard D.W. Kelly,
- Kristy R. Stengel,
- Aditya Chandru,
- Lyndsey C. Johnson,
- Scott W. Hiebert,
- and Shaun M. Cowley
Genome Res. January 2024 34: 34-46; Published in Advance January 30, 2024, doi:10.1101/gr.278050.123
...run-on and sequencing (PRO-seq) to examine their roles in defining the ESC transcriptome. Both LBH589 and JQ1 cause a marked reduction in the pluripotent gene network. However, although JQ1 treatment induces widespread transcriptional pausing, HDAC inhibition causes a reduction in both paused...
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Method: Network-based hierarchical population structure analysis for large genomic data sets
- Gili Greenbaum,
- Amir Rubin,
- Alan R. Templeton,
- and Noah A. Rosenberg
Genome Res. December 2019 29: 2020-2033; Published in Advance November 6, 2019, doi:10.1101/gr.250092.119
...-Saharan African populations. Our network-based approach is able to identify finer-scale structure for many groups in these regions. In central and western Africa, Biaka, Mandenka, Mbuti, and Yoruba are each clustered to a different leaf cluster, with each cluster consisting of individuals from a single group...
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Method: Characterization of network hierarchy reflects cell state specificity in genome organization
- Jingyao Wang,
- Yue Xue,
- Yueying He,
- Hui Quan,
- Jun Zhang,
- and Yi Qin Gao
Genome Res. February 2023 33: 247-260; Published in Advance February 24, 2023, doi:10.1101/gr.277206.122
...Characterization of network hierarchy reflects cell state specificity in organization Jingyao Wang1,4, Yue Xue1,4, Yueying He1, Hui Quan1, Jun Zhang3 and Yi Qin Gao1,2,3 1Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing...

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