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PERSPECTIVE: What is a gene, post-ENCODE? History and updated definition
- Mark B. Gerstein,
- Can Bruce,
- Joel S. Rozowsky,
- Deyou Zheng,
- Jiang Du,
- Jan O. Korbel,
- Olof Emanuelsson,
- Zhengdong D. Zhang,
- Sherman Weissman,
- and Michael Snyder
Genome Res. June 2007 17: 669-681; doi:10.1101/gr.6339607
...What is a gene, post-ENCODE? History and updated definition Mark B. Gerstein 1 , 2 , 3 , 9 , Can Bruce 2 , 4 , Joel S. Rozowsky 2 , Deyou Zheng 2 , Jiang Du 3 , Jan O. Korbel 2 , 5 , Olof Emanuelsson 6...
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Resource: Discovery of high-confidence human protein-coding genes and exons by whole-genome PhyloCSF helps elucidate 118 GWAS loci
- Jonathan M. Mudge,
- Irwin Jungreis,
- Toby Hunt,
- Jose Manuel Gonzalez,
- James C. Wright,
- Mike Kay,
- Claire Davidson,
- Stephen Fitzgerald,
- Ruth Seal,
- Susan Tweedie,
- Liang He,
- Robert M. Waterhouse,
- Yue Li,
- Elspeth Bruford,
- Jyoti S. Choudhary,
- Adam Frankish,
- and Manolis Kellis
Genome Res. December 2019 29: 2073-2087; Published in Advance September 19, 2019, doi:10.1101/gr.246462.118
...-generation transcriptomic data sets, and mass spectrometry evidence of translation for several new genes. Our discoveries required simultaneous comparative annotation of other vertebrate s, which we show is essential to remove spurious ORFs and to distinguish coding from pseudogene regions. Our new coding regions help...
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