Searching journal content for articles similar to Mousses et al. 13 (10): 2341.

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  1. Research: Widespread association of the Argonaute protein AGO2 with meiotic chromatin suggests a distinct nuclear function in mammalian male reproduction
    • Kimberly N. Griffin,
    • Benjamin William Walters,
    • Haixin Li,
    • Huafeng Wang,
    • Giulia Biancon,
    • Toma Tebaldi,
    • Carolyn B. Kaya,
    • Jean Kanyo,
    • TuKiet T. Lam,
    • Andy L. Cox,
    • Stephanie Halene,
    • Jean-Ju Chung,
    • and Bluma J. Lesch
    Genome Res. September 2022 32: 1655-1668; Published in Advance September 15, 2022, doi:10.1101/gr.276578.122
    ...proteins. Correspondingly, Ago2 cKO males show abnormal sperm head morphology and reduced sperm count, along with reduced postnatal viability of offspring. Together, our data reveal an unexpected nuclear role for AGO2 in enhancing expression of developmentally important genes during mammalian male...
  2. Research: Global analyses of the dynamics of mammalian microRNA metabolism
    • Elena R. Kingston and
    • David P. Bartel
    Genome Res. November 2019 29: 1777-1790; Published in Advance September 13, 2019, doi:10.1101/gr.251421.119
    ...of miR-7 by the Oip5os1 (also known as Cyrano) long noncoding RNA (lncRNA) in mammalian tissues (Kleaveland et al. 2018).Questions also remain regarding the rates of miRNA turnover and the extent to which degradation is regulated in a miRNA-specific manner. Most miRNAs that have been examined are highly...
  3. Method: Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cells
    • Arshad H. Khan,
    • Andy Lin,
    • Richard T. Wang,
    • Joshua S. Bloom,
    • Kenneth Lange,
    • and Desmond J. Smith
    Genome Res. October 2020 30: 1458-1467; Published in Advance September 2, 2020, doi:10.1101/gr.262204.120
    ...power and resolution and should be a useful addition to the mammalian genetic toolkit.A variety of experimental strategies have been developed over the last two decades to explore genotype–phenotype correlations in mammalian cells. Gene “knockdowns” use either interfering RNA (RNAi) or small interfering...
  4. Method: ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens
    • Diane D. Shao,
    • Aviad Tsherniak,
    • Shuba Gopal,
    • Barbara A. Weir,
    • Pablo Tamayo,
    • Nicolas Stransky,
    • Steven E. Schumacher,
    • Travis I. Zack,
    • Rameen Beroukhim,
    • Levi A. Garraway,
    • Adam A. Margolin,
    • David E. Root,
    • William C. Hahn,
    • and Jill P. Mesirov
    Genome Res. April 2013 23: 665-678; Published in Advance December 26, 2012, doi:10.1101/gr.143586.112
    ...ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens Diane D. Shao 1 , 2 , 6 , Aviad Tsherniak 1 , 6 , Shuba Gopal 1 , Barbara A. Weir 1 , Pablo Tamayo 1 , Nicolas Stransky 1 , 7...
  5. Review: A systematic guide for identifying transcription factors that directly regulate the expression of a gene of interest
    • Andrew D. Bates,
    • Dawid Grzela,
    • Maciej Studzian,
    • Louise Brennan,
    • Moli Williams,
    • Conor Fawcett,
    • Beth Hammond,
    • Manreen Grewal,
    • Marcin Ratajewski,
    • Lukasz Pulaski,
    • and Urszula L. McClurg
    Genome Res. March 2026 36: 433-459; Published in Advance February 17, 2026, doi:10.1101/gr.281154.125
    ...in any eukaryotic organism, TSSPlant (Shahmuradov et al. 2017) designed for plant TSS prediction, and machine learning-enhanced options like DeePromoter (Oubounyt et al. 2019) designed exclusively for mammalian TSSs. Newer CamoTSS specifically calls TSS from actual RNA-seq data (Hou et al. 2023).Most...
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  6. Research: Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1–S6K pathway signaling
    • Robert A. Lindquist,
    • Kathleen A. Ottina,
    • Douglas B. Wheeler,
    • Peggy P. Hsu,
    • Carson C. Thoreen,
    • David A. Guertin,
    • Siraj M. Ali,
    • Shomit Sengupta,
    • Yoav D. Shaul,
    • Michael R. Lamprecht,
    • Katherine L. Madden,
    • Adam R. Papallo,
    • Thouis R. Jones,
    • David M. Sabatini,
    • and Anne E. Carpenter
    Genome Res. March 2011 21: 433-446; Published in Advance January 14, 2011, doi:10.1101/gr.111492.110
    ...Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1–S6K pathway signaling Robert A. Lindquist 1 , Kathleen A. Ottina 1 , Douglas B. Wheeler 1 , Peggy P. Hsu 1 , 2 , Carson C. Thoreen 1...
  7. LETTER: Defining the mammalian CArGome
    • Qiang Sun,
    • Guang Chen,
    • Jeffrey W. Streb,
    • Xiaochun Long,
    • Yumei Yang,
    • Christian J. Stoeckert, Jr.,
    • and Joseph M. Miano
    Genome Res. February 2006 16: 197-207; Published in Advance December 19, 2005, doi:10.1101/gr.4108706
    ...Defining the mammalian CArGome Qiang Sun 1 , 5 , Guang Chen 2 , 3 , 5 , Jeffrey W. Streb 1 , 5 , Xiaochun Long 1 , Yumei Yang 1 , Christian J. Stoeckert, Jr. 2 , 4 , and Joseph M. Miano 1 , 6 1...
  8. Methods: High-Throughput Selection of Effective RNAi Probes for Gene Silencing
    • Rajeev Kumar,
    • Douglas S. Conklin,
    • and Vivek Mittal
    Genome Res. October 2003 13: 2333-2340; doi:10.1101/gr.1575003
    ...al. 2003 ). They would also be useful where lethality associated with complete suppression of critical genes is of concern. A High-Throughput Selection of siRNA Probes by RNAi Microarrays Currently a major effort is geared towards using RNAi as a reverse genetic approach for analyzing mammalian gene...
  9. Research: Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species
    • Dan Xie,
    • Chieh-Chun Chen,
    • Leon M. Ptaszek,
    • Shu Xiao,
    • Xiaoyi Cao,
    • Fang Fang,
    • Huck H. Ng,
    • Harris A. Lewin,
    • Chad Cowan,
    • and Sheng Zhong
    Genome Res. June 2010 20: 804-815; Published in Advance March 10, 2010, doi:10.1101/gr.100594.109
    ...Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species Dan Xie 1 , 9 , Chieh-Chun Chen 1 , 9 , Leon M. Ptaszek 2 , 3 , 4 , 9 , Shu Xiao 1 , Xiaoyi Cao 5 , Fang Fang 6...
  10. Research: Histone deacetylases maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and noncoding loci
    • Richard D.W. Kelly,
    • Kristy R. Stengel,
    • Aditya Chandru,
    • Lyndsey C. Johnson,
    • Scott W. Hiebert,
    • and Shaun M. Cowley
    Genome Res. January 2024 34: 34-46; Published in Advance January 30, 2024, doi:10.1101/gr.278050.123
    .... Among the 18 HDAC enzymes present within mammalian cells, HDAC1, HDAC2, and HDAC3 (class I HDACs) have well-described roles in regulating gene expression as the catalytic core of seven multiprotein complexes: SIN3, NuRD, CoREST, MiDAC, MIER and RERE (HDAC1 and HDAC2), and NCoR (HDAC3) (Millard et al...
    OPEN ACCESS ARTICLE
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