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Perspective: Understanding the regulatory and transcriptional complexity of the genome through structure
- Tim R. Mercer and
- John S. Mattick
Genome Res. July 2013 23: 1081-1088; doi:10.1101/gr.156612.113
...C, Kress C, Bickmore WA. 2009. Lack of bystander activation shows that localization exterior to chromosome territories is not sufficient to up-regulate gene expression. Genome Res 19: 1184–1194. Nemeth A, Langst G. 2011. Genome organization in and around the nucleolus. Trends Genet 27: 149–156. Neph...
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Research: Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation
- Ofir Hakim,
- Myong-Hee Sung,
- Shingo Nakayamada,
- Ty C. Voss,
- Songjoon Baek,
- and Gordon L. Hager
Genome Res. March 2013 23: 462-472; Published in Advance December 3, 2012, doi:10.1101/gr.147652.112
...) and Gata3, the gene encoding GATA binding protein 3, the master transcriptional regulator for the Th2 lineage. Indeed, the Th2 cytokine locus (chromosome 11) is preferentially associated with Gata3 (chromosome 2) in Th2 cells (Fig. 1B). These cell type-specific differences in interchromosomal association...

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