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Research: KRAB zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution
- Kai Otsuka,
- Akihiko Sakashita,
- So Maezawa,
- Richard M. Schultz,
- and Satoshi H. Namekawa
Genome Res. March 2025 35: 417-431; Published in Advance March 12, 2025, doi:10.1101/gr.279924.124
...elements (LTRs).Testis-specific expression of ERVs in humans and mice was initially reported over 40 years ago (Del Villano and Lerner 1976), and recent studies reveal regulatory functions for TEs in male meiosis. These functions include post-transcriptional regulation of mRNA and long noncoding RNAs (lnc...
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Research: Genome-wide relaxation of selection and the evolution of the island syndrome in Orkney voles
- Xuejing Wang and
- Gerald Heckel
Genome Res. June 2024 34: 851-862; Published in Advance July 2, 2024, doi:10.1101/gr.278487.123
...(Table 1). The genes belonging to the term histone H2A-K119 monoubiquitination include BMI1 and several PCGF genes and are regulated by insulin-like growth factors in mammals (Nacerddine et al. 2012). A series of cytochrome P450 genes in the second most significant term, epoxygenase P450, all of which...

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