Searching journal content for articles similar to Miles et al. 26 (9): 1288.

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  1. Research: Variation in the fitness impact of translationally optimal codons among animals
    • Florian Bénitière,
    • Tristan Lefébure,
    • and Laurent Duret
    Genome Res. March 2025 35: 446-458; Published in Advance February 10, 2025, doi:10.1101/gr.279837.124
    ...variation among metazoansTo investigate the factors driving the intensity of TS in metazoans, we used the GTDrift database, which compiles genomic and transcriptomic data along with life history traits and proxies of Ne for various eukaryotic species (Bénitière et al. 2024). We initially selected 257...
  2. Resource: Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii
    • The Anopheles gambiae 1000 Genomes Consortium
    Genome Res. October 2020 30: 1533-1546; Published in Advance September 28, 2020, doi:10.1101/gr.262790.120
    ..., making a valuable comparison. Among other eukaryotes, comparable data resources exist only for humans (The 1000 Genomes Project Consortium 2015) and malaria parasites (MalariaGEN Plasmodium falciparum Community Project 2019), and thus, there remains an absence of open genomic data for studying...
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  3. Research: Whole-genome sequencing reveals high complexity of copy number variation at insecticide resistance loci in malaria mosquitoes
    • Eric R. Lucas,
    • Alistair Miles,
    • Nicholas J. Harding,
    • Chris S. Clarkson,
    • Mara K.N. Lawniczak,
    • Dominic P. Kwiatkowski,
    • David Weetman,
    • Martin J. Donnelly,
    • and The Anopheles gambiae 1000 Genomes Consortium
    Genome Res. August 2019 29: 1250-1261; Published in Advance July 25, 2019, doi:10.1101/gr.245795.118
    ...countries intensifies and as the operational deployment of next-generation bed nets targeting metabolic resistance gathers pace. Our detailed descriptions of CNVs found across the species range provide the tools to do so.Copy number variants (CNVs) are a form of genetic variation that occur when a genomic...
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  4. Method: Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy-chain locus
    • Mari B. Gornitzka,
    • Egil Røsjø,
    • Uddalok Jana,
    • Easton E. Ford,
    • Alan Tourancheau,
    • William D. Lees,
    • Zachary Vanwinkle,
    • Melissa L. Smith,
    • Corey T. Watson,
    • and Andreas Lossius
    Genome Res. October 2025 35: 2240-2251; Published in Advance August 21, 2025, doi:10.1101/gr.280400.125
    ...al. 2016), and Plasmodium falciparum (Tan et al. 2018). Recent studies have also uncovered considerable unexplored germline variation within the IGHC genes (Calonga-Solís et al. 2019; Bashirova et al. 2021; Ford et al. 2023). Polymorphisms in the IGHC region can influence Fc receptor binding and...
  5. Method: Detection of simple and complex de novo mutations with multiple reference sequences
    • Kiran V. Garimella,
    • Zamin Iqbal,
    • Michael A. Krause,
    • Susana Campino,
    • Mihir Kekre,
    • Eleanor Drury,
    • Dominic Kwiatkowski,
    • Juliana M. Sá,
    • Thomas E. Wellems,
    • and Gil McVean
    Genome Res. August 2020 30: 1154-1169; Published in Advance August 19, 2020, doi:10.1101/gr.255505.119
    ....ResultsMissing genomic novelty in reference-based analysisWe motivate the development of a reference-unbiased DNM discovery tool by first exploring discrepancies in genomic novelty identified by reference-based versus reference-free analyses. We examined 20 high-coverage Plasmodium falciparum samples, the etiological...
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  6. Method: Single-cell genomics for dissection of complex malaria infections
    • Shalini Nair,
    • Standwell C. Nkhoma,
    • David Serre,
    • Peter A. Zimmerman,
    • Karla Gorena,
    • Benjamin J. Daniel,
    • François Nosten,
    • Timothy J.C. Anderson,
    • and Ian H. Cheeseman
    Genome Res. June 2014 24: 1028-1038; Published in Advance May 8, 2014, doi:10.1101/gr.168286.113
    ...applied this validated approach directly to infections of two major malaria species, Plasmodium falciparum, for which long term culture is possible, and Plasmodium vivax, for which no long-term culture is feasible. We demonstrate that our single-cell genomics approach can be used to generate parasite...
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