Searching journal content for articles similar to Mikulasova et al. 32 (7): 1343.

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  1. Research: MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sites
    • Yi Xiang See,
    • Kaijing Chen,
    • and Melissa J. Fullwood
    Genome Res. April 2022 32: 629-642; Published in Advance February 3, 2022, doi:10.1101/gr.276313.121
    ...preferentially to super-enhancers to perform its oncogenic functions. In this paper, we use the U2OS cell line with a tetracycline-inducible MYC system, which has been widely used for the study of transcriptional regulation by MYC (Walz et al. 2014; Lorenzin et al. 2016; de Pretis et al. 2017; Nie et al. 2020...
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  2. Research: Dynamics of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes
    • Mohamed Belhocine,
    • Mathieu Simonin,
    • José David Abad Flores,
    • Agata Cieslak,
    • Iris Manosalva,
    • Lydie Pradel,
    • Charlotte Smith,
    • Eve-Lyne Mathieu,
    • Guillaume Charbonnier,
    • Joost H.A. Martens,
    • Hendrik G. Stunnenberg,
    • Muhammad Ahmad Maqbool,
    • Aneta Mikulasova,
    • Lisa J. Russell,
    • Daniel Rico,
    • Denis Puthier,
    • Pierre Ferrier,
    • Vahid Asnafi,
    • and Salvatore Spicuglia
    Genome Res. July 2022 32: 1328-1342; Published in Advance June 23, 2021, doi:10.1101/gr.266924.120
    ...oncogene expression, such as in the cases of TAL1, TLX1, or TLX3 oncogenes, is a direct consequence of genomic alterations. In these cases, the presence of the broad H3K4me3 domain is associated with the hijacking of a T cell–specific enhancer or super-enhancer (Fig. 3), leading to an epigenetic...
  3. Method: High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation
    • Daniel Rico,
    • Daniel Kent,
    • Nefeli Karataraki,
    • Aneta Mikulasova,
    • Rolando Berlinguer-Palmini,
    • Brian A. Walker,
    • Biola M. Javierre,
    • Lisa J. Russell,
    • and Chris A. Brackley
    Genome Res. July 2022 32: 1355-1366; Published in Advance July 21, 2022, doi:10.1101/gr.276028.121
    ...(while losing H3K4me1 and H3K27me3 at the promoter). These features are consistent with H3K4me3 broad domains, which have previously been associated with super-enhancers (Thibodeau et al. 2017; Dhar et al. 2018). Their appearance has been implicated in cancer-specific super-enhancer hijacking at a number...
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