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LETTER: Cloning of Two Human Homologs of the Drosophila single-minded Gene SIM1 on Chromosome 6q and SIM2 on 21q Within the Down Syndrome Chromosomal Region
- Roman Chrast,
- Hamish S. Scott,
- Haiming Chen,
- Jun Kudoh,
- Colette Rossier,
- Shinsei Minoshima,
- Yimin Wang,
- Nobuyoshi Shimizu,
- and Stylianos E. Antonarakis
Genome Res. June 1, 1997 7: 615-624; doi:10.1101/gr.7.6.615
...Cloning of Two Human Homologs of the Drosophila single-minded Gene SIM1 on Chromosome 6q and SIM2 on 21q Within the Down Syndrome Chromosomal Region Roman Chrast 1 , 2 , Hamish S. Scott 1 , Haiming Chen 1 , Jun Kudoh 4 , Colette Rossier 1...
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LETTER: Noncoding Sequences Conserved in a Limited Number of Mammals in the SIM2 Interval are Frequently Functional
- Kelly A. Frazer,
- Heng Tao,
- Kazutoyo Osoegawa,
- Pieter J. de Jong,
- Xiyin Chen,
- Mark F. Doherty,
- and David R. Cox
Genome Res. March 2004 14: 367-372; Published in Advance February 12, 2004, doi:10.1101/gr.1961204
...of the single-minded 2 ( SIM2 ) gene interval on human chromosome 21 with horse, cow, pig, dog, cat, and mouse DNA. We classify conserved sequences based on the number of mammals in which they are present, and experimentally test sequences in each class for function. As hypothesized, conserved sequences present...
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LETTER: Evolutionarily Conserved Sequences on Human Chromosome 21
- Kelly A. Frazer,
- John B. Sheehan,
- Renee P. Stokowski,
- Xiyin Chen,
- Roya Hosseini,
- Jan-Fang Cheng,
- Stephen P.A. Fodor,
- David R. Cox,
- and Nila Patil
Genome Res. October 1, 2001 11: 1651-1659; doi:10.1101/gr.198201
...elements identified by hybridizing a 100-kb interval (upstream and encoding the 5′ end of the single-minded [ SIM2 ] gene) with dog and mouse DNA. The conserved elements are shown relative to their position in the human reference sequence ( horizontal axis) and their percent conformances ( vertical axis...
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ARTICLE: Cloning of 559 potential exons of genes of human chromosome 21 by exon trapping.
- H Chen,
- R Chrast,
- C Rossier,
- M A Morris,
- M D Lalioti,
- and S E Antonarakis
Genome Res. August 1996 6: 747-760; doi:10.1101/gr.6.8.747
.... Antonarakis, S.E. Kudoh, J. Yamaki, A. Shindoh, N. Maeda, H. Minoshima, S. and Shimizu. N. 1995b . Single-minded and Down syndrome? Nature Genet. 10 : 9 – 10 . Cheng, J.F., , Boyartchuk, V. , Zhu. Y. Cheng, J.F., Boyartchuk, V. and Zhu. Y. 1994 . Isolation and mapping of human chromosome 21 cDNA: Progress...
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LETTER: A Comprehensive Analysis of Allelic Methylation Status of CpG Islands on Human Chromosome 21q
- Yoichi Yamada,
- Hidemi Watanabe,
- Fumihito Miura,
- Hidenobu Soejima,
- Michiko Uchiyama,
- Tsuyoshi Iwasaka,
- Tsunehiro Mukai,
- Yoshiyuki Sakaki,
- and Takashi Ito
Genome Res. February 2004 14: 247-266; doi:10.1101/gr.1351604
...A Comprehensive Analysis of Allelic Methylation Status of CpG Islands on Human Chromosome 21q Yoichi Yamada 1 , 2 , Hidemi Watanabe 3 , 4 , Fumihito Miura 1 , 2 , Hidenobu Soejima 5 , Michiko Uchiyama 6 , Tsuyoshi Iwasaka 6...
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LETTER: A First-Generation Whole Genome–Radiation Hybrid Map Spanning the Mouse Genome
- Linda C. McCarthy,
- Jonathan Terrett,
- Maria E. Davis,
- Catherine J. Knights,
- Angela L. Smith,
- Ricky Critcher,
- Karin Schmitt,
- Jim Hudson,
- Nigel K. Spurr,
- and Peter N. Goodfellow
Genome Res. December 1, 1997 7: 1153-1161; doi:10.1101/gr.7.12.1153
.... , Maeda H. , Minoshima S. , Kawasaki K. , Shimizu Y. , Shimizu N. ( 1996 ) The mammalian single-minded (SIM) gene—mouse cDNA structure and dicephalic expression indicate a candidate gene for Down Syndrome. Genomics 35 : 136 – 143 . A First-Generation Whole Genome–Radiation Hybrid Map Spanning the Mouse...
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ARTICLE: Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.
- M Ohira,
- N Seki,
- T Nagase,
- E Suzuki,
- N Nomura,
- O Ohara,
- M Hattori,
- Y Sakaki,
- T Eki,
- Y Murakami,
- T Saito,
- H Ichikawa,
- and M Ohki
Genome Res. January 1997 7: 47-58; doi:10.1101/gr.7.1.47
.... , Rossier, C. , Gos, A. , Antonarakis, S.E. , Kudoh, J. , Yamaki, A. , Shindo, N. , Maeda, H. , Minoshima, S. , Shimizu. N. Chen, H., Chrast, R. Rossier, C. Gos, A. Antonarakis, S.E. Kudoh, J. Yamaki, A. Shindo, N. Maeda, H. Minoshima, S. and Shimizu. N. 1995 . Single-minded and Down syndrome? Nature Genet...
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LETTER: The Basic Helix-Loop-Helix Protein Family: Comparative Genomics and Phylogenetic Analysis
- Valérie Ledent and
- Michel Vervoort
Genome Res. May 1, 2001 11: 754-770; doi:10.1101/gr.177001
..., so called for the first three proteins identified with this motif: Drosophila Period (Per), human ARNT, and Drosophila Single-minded (Sim). The PAS domain found in bHLH-PAS proteins is ∼260–310 amino acids long and allows the dimerization between PAS proteins, the binding of small molecules (e...
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ARTICLE: Analysis of Conserved Noncoding DNA in Drosophila Reveals Similar Constraints in Intergenic and Intronic Sequences
- Casey M. Bergman and
- Martin Kreitman
Genome Res. August 1, 2001 11: 1335-1345; doi:10.1101/gr.178701
...and functional analysis of conserved noncoding DNA. RESULTS The results of our survey for noncoding regions exhibiting primary sequence conservation in Drosophila identified the 40 loci in Table 1 . The loci are scattered among all five major chromosomal arms of the D. melanogaster , and therefore reflect...

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