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Research: Distinct classes of lamina-associated domains are defined by differential patterns of repressive histone methylation
- Caden J. Martin,
- Elizabeth A. Oser,
- Prabakaran Nagarajan,
- Liudmila V. Popova,
- Benjamin D. Sunkel,
- Benjamin Z. Stanton,
- and Mark R. Parthun
Genome Res. September 2025 35: 1959-1974; Published in Advance August 5, 2025, doi:10.1101/gr.280380.124
...and Belmont 2017; Falk et al. 2019).Lamina-associated domains (LADs) are large, heterochromatic regions of the that interact with the transcriptionally repressive environment of the nuclear lamina. Some LADs are conserved across development, whereas others interact with the lamina only in particular cell...
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Research: Massive reshaping of genome–nuclear lamina interactions during oncogene-induced senescence
- Christelle Lenain,
- Carolyn A. de Graaf,
- Ludo Pagie,
- Nils L. Visser,
- Marcel de Haas,
- Sandra S. de Vries,
- Daniel Peric-Hupkes,
- Bas van Steensel,
- and Daniel S. Peeper
Genome Res. October 2017 27: 1634-1644; Published in Advance September 15, 2017, doi:10.1101/gr.225763.117
...in cellular senescence and organismal aging. It interacts with multiple regions of the called lamina-associated domains (LADs). Some LADs are cell-type specific, whereas others are conserved between cell types and are referred to as constitutive LADs (cLADs). Here, we used DamID to investigate the changes...
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Method: TSA-seq reveals a largely conserved genome organization relative to nuclear speckles with small position changes tightly correlated with gene expression changes
- Liguo Zhang,
- Yang Zhang,
- Yu Chen,
- Omid Gholamalamdari,
- Yuchuan Wang,
- Jian Ma,
- and Andrew S. Belmont
Genome Res. February 2021 31: 251-264; Published in Advance December 18, 2020, doi:10.1101/gr.266239.120
...expression correlates inversely with distance to nuclear speckles, with chromosome regions of unusually high expression located at the apex of chromosome loops protruding from the nuclear periphery into the interior. Genomic distances to the nearest lamina-associated domain are larger for loop apexes mapping...
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Research: Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments
- Michael I. Robson,
- Jose I. de las Heras,
- Rafal Czapiewski,
- Aishwarya Sivakumar,
- Alastair R.W. Kerr,
- and Eric C. Schirmer
Genome Res. July 2017 27: 1126-1138; Published in Advance April 19, 2017, doi:10.1101/gr.212308.116
.... The nuclear periphery, in contrast, contributes radial organization. Genome regions proximal to the lamin intermediate filament polymer lining the inner nuclear membrane are called lamina-associated domains (LADs) (Guelen et al. 2008). However, while they are implicated in organization (Mewborn et al. 2010...
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Research: A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha
- Kevin Gesson,
- Philipp Rescheneder,
- Michael P. Skoruppa,
- Arndt von Haeseler,
- Thomas Dechat,
- and Roland Foisner
Genome Res. April 2016 26: 462-473; Published in Advance January 21, 2016, doi:10.1101/gr.196220.115
.... Abstract Lamins are components of the peripheral nuclear lamina and interact with heterochromatic genomic regions, termed lamina-associated domains (LADs). In contrast to lamin B1 being primarily present at the nuclear periphery, lamin A/C also localizes throughout the nucleus, where it associates...
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Research: Diploid genome architecture revealed by multi-omic data of hybrid mice
- Zhijun Han,
- Kairong Cui,
- Katarzyna Placek,
- Ni Hong,
- Chengqi Lin,
- Wei Chen,
- Keji Zhao,
- and Wenfei Jin
Genome Res. August 2020 30: 1097-1106; Published in Advance August 5, 2020, doi:10.1101/gr.257568.119
....1186/1471-2121-6-44 ↵Meuleman W, Peric-Hupkes D, Kind J, Beaudry JB, Pagie L, Kellis M, Reinders M, Wessels L, van Steensel B. 2013. Constitutive nuclear lamina– interactions are highly conserved and associated with A/T-rich sequence. Genome Res 23: 270–280. doi:10.1101/gr.141028.112 ↵Nagano T, Lubling Y, Várnai C, Dudley C...
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Research: Prepatterning of differentiation-driven nuclear lamin A/C-associated chromatin domains by GlcNAcylated histone H2B
- Torunn Rønningen,
- Akshay Shah,
- Anja R. Oldenburg,
- Kristin Vekterud,
- Erwan Delbarre,
- Jan Øivind Moskaug,
- and Philippe Collas
Genome Res. December 2015 25: 1825-1835; Published in Advance September 10, 2015, doi:10.1101/gr.193748.115
..., Norway Corresponding author: philippe.collas@medisin.uio.no ↵ 3 These authors contributed equally to this work. Abstract Dynamic interactions of nuclear lamins with chromatin through lamin-associated domains (LADs) contribute to spatial arrangement of the genome...
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Research: Lamin A/C-promoter interactions specify chromatin state–dependent transcription outcomes
- Eivind Lund,
- Anja R. Oldenburg,
- Erwan Delbarre,
- Christel T. Freberg,
- Isabelle Duband-Goulet,
- Ragnhild Eskeland,
- Brigitte Buendia,
- and Philippe Collas
Genome Res. October 2013 23: 1580-1589; Published in Advance July 16, 2013, doi:10.1101/gr.159400.113
...and after LMNA KD. (D) Number of genes with a LMNA-associated promoter in ASCs and in LMNA-KD ASCs. (E ) GAGA and A/T-rich motifs enriched in promoter regions underlying LMNA peaks. Genome Research 1581 www..org Expression output of lamin-promoter interactions cluster or are uniformly distributed...
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Research: Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments
- Vlad C. Seitan,
- Andre J. Faure,
- Ye Zhan,
- Rachel Patton McCord,
- Bryan R. Lajoie,
- Elizabeth Ing-Simmons,
- Boris Lenhard,
- Luca Giorgetti,
- Edith Heard,
- Amanda G. Fisher,
- Paul Flicek,
- Job Dekker,
- and Matthias Merkenschlager
Genome Res. December 2013 23: 2066-2077; Published in Advance September 3, 2013, doi:10.1101/gr.161620.113
...organization. The underlying mechanisms are beginning to be explored in terms of the biophysical properties of the DNA polymer and associated chromatin (Fudenberg and Mirny 2012) and nuclear landmarks such as nuclear lamina that provide genomic scaffolds (Guelen et al. 2008; McCord et al. 2013; Meuleman et al...
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Research: A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?
- Arkarachai Fungtammasan,
- Erin Walsh,
- Francesca Chiaromonte,
- Kristin A. Eckert,
- and Kateryna D. Makova
Genome Res. June 2012 22: 993-1005; Published in Advance March 28, 2012, doi:10.1101/gr.134395.111
...coverage are significant predictors. Also, aCFSs have high fragility when colocated with evolutionarily conserved chromosomal breakpoints. Our models are predictive of the fragility of aCFSs mapped at a higher resolution. Importantly, the genomic features we identified here as significant predictors...

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