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Research: Ancient exapted transposable elements promote nuclear enrichment of human long noncoding RNAs
- Joana Carlevaro-Fita,
- Taisia Polidori,
- Monalisa Das,
- Carmen Navarro,
- Tatjana I. Zoller,
- and Rory Johnson
Genome Res. February 2019 29: 208-222; Published in Advance December 26, 2018, doi:10.1101/gr.229922.117
...author: rory.johnson@dbmr.unibe.chAbstractThe sequence domains underlying long noncoding RNA (lncRNA) activities, including their characteristic nuclear enrichment, remain largely unknown. It has been proposed that these domains can originate from neofunctionalized fragments of transposable elements (TEs...
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PERSPECTIVE: Comparing the human and chimpanzee genomes: Searching for needles in a haystack
- Ajit Varki and
- Tasha K. Altheide
Genome Res. December 2005 15: 1746-1758; doi:10.1101/gr.3737405
...that a gene has undergone positive selection ( Dorus et al. 2004 ). Also, a protein could have only one or a few important amino acid changes, perhaps confined to a critical domain, motif, or site ( Andres et al. 2004 ; Sonnenburg et al. 2004 ), and thus not have an elevated K a relative to K s. Careful...

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