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Research: Genomic architecture constrained placental mammal X Chromosome evolution
- Wesley A. Brashear,
- Kevin R. Bredemeyer,
- and William J. Murphy
Genome Res. August 2021 31: 1353-1365; Published in Advance July 22, 2021, doi:10.1101/gr.275274.121
...hybrid, a phenomenon previously described in interspecific rodent crosses (Deng et al. 2015; Darrow et al. 2016).View larger version: In this window In a new window Figure 5. Spatial organization of loci previously associated with X Chromosome structural organization. (A) Hi-C contact map of the domestic...
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Method: A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes
- Andy Lin,
- Richard T. Wang,
- Sangtae Ahn,
- Christopher C. Park,
- and Desmond J. Smith
Genome Res. August 2010 20: 1122-1132; Published in Advance May 27, 2010, doi:10.1101/gr.104216.109
...A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes Andy Lin 1 , Richard T. Wang 1 , Sangtae Ahn 2 , Christopher C. Park 1 and Desmond J. Smith 1 , 3 1 Department of Molecular and Medical...
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Method: A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission
- Mikhail Liskovykh,
- Nikolay V. Goncharov,
- Nikolai Petrov,
- Vasilisa Aksenova,
- Gianluca Pegoraro,
- Laurent L. Ozbun,
- William C. Reinhold,
- Sudhir Varma,
- Mary Dasso,
- Vadim Kumeiko,
- Hiroshi Masumoto,
- William C. Earnshaw,
- Vladimir Larionov,
- and Natalay Kouprina
Genome Res. October 2019 29: 1719-1732; Published in Advance September 12, 2019, doi:10.1101/gr.254276.119
...for screening different siRNA libraries (cell cycle regulation, DNA damage response, epigenetics, and transcription factors) to identify additional genes involved in CIN. Identification of the complete spectrum of CIN genes will reveal new insights into mechanisms of chromosome segregation and may expedite...
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Research: Genetic variation in radiation-induced cell death
- Denis A. Smirnov,
- Lauren Brady,
- Krzysztof Halasa,
- Michael Morley,
- Sonia Solomon,
- and Vivian G. Cheung
Genome Res. February 2012 22: 332-339; Published in Advance August 15, 2011, doi:10.1101/gr.122044.111
...and cell death in B cells from normal individuals. We found extensive individual variation in gene expression and cellular responses. To understand the genetic basis of this variation, we mapped the DNA sequence variants that influence expression response to radiation. We also identified radiation...
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RESOURCE: Chromosome-Specific Single-Locus FISH Probes Allow Anchorage of an 1800-Marker Integrated Radiation-Hybrid/Linkage Map of the Domestic Dog Genome to All Chromosomes
- Matthew Breen,
- Sophie Jouquand,
- Corinne Renier,
- Cathryn S. Mellersh,
- Christophe Hitte,
- Nigel G. Holmes,
- Angélique Chéron,
- Nicola Suter,
- Françoise Vignaux,
- Anna E. Bristow,
- Catherine Priat,
- E. McCann,
- Catherine André,
- Sam Boundy,
- Paul Gitsham,
- Rachael Thomas,
- Wendy L. Bridge,
- Helen F. Spriggs,
- Ed J. Ryder,
- Alistair Curson,
- Jeff Sampson,
- Elaine A. Ostrander,
- Matthew M. Binns,
- and Francis Galibert
Genome Res. October 1, 2001 11: 1784-1795; doi:10.1101/gr.189401
...integrated, comprehensive map of the canine , incorporating detailed cytogenetic, radiation hybrid (RH), and meiotic information. We have mapped a collection of 266 chromosome-specific cosmid clones, each containing a microsatellite marker, to all 38 canine autosomes by fluorescence in situ hybridization...
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RESEARCH: An STS-Based Radiation Hybrid Map of the Human Genome
- Elizabeth A. Stewart,
- Kathleen B. McKusick,
- Amita Aggarwal,
- Ewa Bajorek,
- Shannon Brady,
- Angela Chu,
- Nicole Fang,
- David Hadley,
- Mark Harris,
- Sami Hussain,
- Richard Lee,
- Annu Maratukulam,
- Kyle O’Connor,
- Shanti Perkins,
- Mark Piercy,
- Fawn Qin,
- Tim Reif,
- Carla Sanders,
- Xiaohong She,
- Wei-Lin Sun,
- Poroshat Tabar,
- Susan Voyticky,
- Sid Cowles,
- Jian-Bing Fan,
- Chris Mader,
- John Quackenbush,
- Richard M. Myers,
- and David R. Cox
Genome Res. May 1, 1997 7: 422-433; doi:10.1101/gr.7.5.422
...such reagent is the TNG panel of whole- RHs generated at the Stanford Human Genome Center. This reagent contains sufficient radiation-induced chromosomal breaks to generate high-confidence 100-kb maps ( Lunetta et al. 1996 ). Further studies with these TNG hybrids, along with the development of statistical...
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LETTER: High-Resolution Transcript Map of the Region Spanning D12S1629 and D12S312 at Chromosome 12q13: Triple A Syndrome-Linked Region
- Hyoungnam Lee,
- Eunkyung Choi,
- Young Seomun,
- K. Montgomery,
- A. Huebner,
- Eunice Lee,
- Stephanie Lau,
- Choun-Ki Joo,
- R. Kucherlapati,
- and Sung-Joo Kim Yoon
Genome Res. October 1, 2000 10: 1561-1567; doi:10.1101/gr.142100
...constructed a high-resolution transcript map with PAC/BAC/cosmid clones. The strategy for the construction of such a map involved utilization of STSs for the screening of the large insert bacterial chromosome libraries and a chromosome 12-specific cosmid library by hybridization. The contig was constructed...
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RESOURCE: Human Genome Anatomy: BACs Integrating the Genetic and Cytogenetic Maps for Bridging Genome and Biomedicine
- Julie R. Korenberg,
- Xiao-Ning Chen,
- Zhiguang Sun,
- Zheng-Yang Shi,
- Shaowu Ma,
- Eddy Vataru,
- Dean Yimlamai,
- Jean S. Weissenbach,
- Hiroaki Shizuya,
- Melvin I. Simon,
- Sebastian S. Gerety,
- Huy Nguyen,
- Irina S. Zemsteva,
- Lester Hui,
- James Silva,
- Xiaoyun Wu,
- Bruce W. Birren,
- and Thomas J. Hudson
Genome Res. October 1, 1999 9: 994-1001; doi:10.1101/gr.9.10.994
...-content of large insert yeast artificial chromosome (YAC) clones, radiation hybrid (RH) mapping, and genetic mapping ( Hudson et al. 1995 ; Deloukas et al. 1998 ), or BAC-based, with order obtained at 2–6 Mb through high resolution mapping by fluorescence in situ hybridization (FISH) with respect to human...
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LETTER: Extensive Conservation of Sex Chromosome Organization Between Cat and Human Revealed by Parallel Radiation Hybrid Mapping
- William J. Murphy,
- Shan Sun,
- Zhang-Qun Chen,
- Jill Pecon-Slattery,
- and Stephen J. O'Brien
Genome Res. December 1, 1999 9: 1223-1230; doi:10.1101/gr.9.12.1223
...R.G. , Aziz N. , Baer E. , Gonzales G. , Krane M.C. , Markovich R. , et al. ( 1997 ) A radiation hybrid map of human chromosome 5 with integration of cytogenetic, genetic, and transcript maps. Genome Res. 7 : 897 – 909 . ↵ Menotti-Raymond M. , David V. , Lyons L.A. , Schäffer A.A. , Tomlin J...
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RESOURCE: A Sequence-Based Integrated Map of Chromosome 22
- William J. Tapper,
- Newton E. Morton,
- Ian Dunham,
- Xiayi Ke,
- and Andrew Collins
Genome Res. July 1, 2001 11: 1290-1295; doi:10.1101/gr.161301
...evidence and retain the existing estimates for the p-arm and centromeric heterochromatin, arguably underestimated, giving a total chromosome length of 50.16 Mb. We present here a map of chromosome 22q that integrates sequence, radiation hybrid, genetic, and cytogenetic data. RESULTS A total of 968 loci...

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