Searching journal content for articles similar to McCord et al. 23 (2): 260.

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  1. ...of lamins with histones and DNA (Kind and van Steensel 2010). Lamin- interactions have been proposed to occur through ‘‘lamin association domains’’ (LADs) (Pickersgill et al. 2006; Guelen et al. 2008;Meulemanet al. 2012;Kind et al. 2013). LADs span 0.1–10megabases (Mb) andmay contain thousands of genes...
  2. ...H3K27me3 (Supplemental Fig. S1D), suggesting possible compensation mechanisms as also observed for H3K27me3 and DNA methylation (Reddington et al. 2013). Next, we investigated the 3D alterations at both global (A/B compartment, long-range, and interchromosome interactions) and local (intra...
  3. ...organization. The underlying mechanisms are beginning to be explored in terms of the biophysical properties of the DNA polymer and associated chromatin (Fudenberg and Mirny 2012) and nuclear landmarks such as nuclear lamina that provide genomic scaffolds (Guelen et al. 2008; McCord et al. 2013; Meuleman et al...
  4. ...and keeping the nucleus and the intact will keep the organism healthy. Then, the cell will be able to maintain integrity of the by preserving DNA in its proper configuration to activate and repress gene expression appropriate for each cell type. Hence, treating NAFLD as a laminopathy and testing approaches...
  5. ...of repetitive DNA arrays during muscle differentiation (Mattout et al. 2011). In addition, expression of progerin, a lamin A mutant causing the premature aging disease, Hutchinson Gilford Progeria Syndrome (HGPS), affects heterochromatin organization (Shumaker et al. 2006; McCord et al. 2013). Interestingly...
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