Searching journal content for articles similar to Martinez et al. 18 (12): 2005.

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  1. ...Institute of Pharmaceutical Chemistry, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland; 8Faculty of Science, University of Zurich, 8057 Zurich, Switzerland In animals, microRNAs frequently form families with related sequences. The functional relevance ofmiRNA families and the relative...
  2. ...functions is often maintained. Here, we use the family of 40 Caenorhabditis elegans insulins to gain insight into the balance between specificity and redundancy. The insulin/insulin-like growth factor (IIS) pathway comprises a single receptor, DAF-2. To date, no single insulin-like peptide recapitulates...
  3. ...(albeitwithout thequantification anddynamics facilitated by our automated methodology). Other large-scale studies include a collection of 366 transcription-factor promoter::GFP reporters (Reece-Hoyes et al. 2007), and of 73 microRNA promoter::GFP reporters (Martinez et al. 2008). Each of these studies generated...
  4. ...slightly smaller than that of humans (http://www.sanger.ac.uk/PostGenomics/encode/ stats.html). Major classes of noncoding RNAs (ncRNAs) such as microRNAs (miRNAs) are also represented in C. elegans (Ruby et al. 2006; Kato et al. 2009). Thus, C. elegans provides a simple but representative model...
  5. ...-siRNAs) and Piwi-interacting RNAs (piRNAs) mainly control gene and transposon expression in the germline, while microRNAs (miRNAs) generally function in post-transcriptional gene silencing in both somatic and germline cells. To provide an evolutionary and developmental perspective on small RNA pathways...
  6. ...-transcriptional regulation. We have performed small RNA sequencing in the nematodes Caenorhabditis elegans , C. briggsae , C. remanei , and Pristionchus pacificus , which have diverged up to 400 million years ago, to establish the repertoire and evolutionary dynamics of miRNAs in these species. In addition to previously...
  7. ...by both RNA binding proteins and microRNAs ( Fig. 2E ). Such networks need themselves to be integrated with spatio-temporal information about gene expression and TF/microRNA activity and with phenotypes conferred by TFs and microRNAs to obtain a comprehensive picture about regulatory networks and how...
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