Searching journal content for articles similar to Marcel et al. 31 (12): 2327.

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  1. Research: Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers
    • Aneta Mikulasova,
    • Daniel Kent,
    • Marco Trevisan-Herraz,
    • Nefeli Karataraki,
    • Kent T.M. Fung,
    • Cody Ashby,
    • Agata Cieslak,
    • Shmuel Yaccoby,
    • Frits van Rhee,
    • Maurizio Zangari,
    • Sharmilan Thanendrarajan,
    • Carolina Schinke,
    • Gareth J. Morgan,
    • Vahid Asnafi,
    • Salvatore Spicuglia,
    • Chris A. Brackley,
    • Anne E. Corcoran,
    • Sophie Hambleton,
    • Brian A. Walker,
    • Daniel Rico,
    • and Lisa J. Russell
    Genome Res. July 2022 32: 1343-1354; Published in Advance December 21, 2021, doi:10.1101/gr.276042.121
    ...of H3K4me3-BD over CCND1 in the latter was associated with overexpression and extensive chromatin accessibility of its gene body. We observed similar cancer-specific H3K4me3-BDs associated with hijacking of super-enhancers of other common oncogenes in B cell (MAF, MYC, and FGFR3/NSD2) and T cell...
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  2. Research: Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways
    • Sanchari Bhattacharyya,
    • Kith Pradhan,
    • Nathaniel Campbell,
    • Jozef Mazdo,
    • Aparna Vasantkumar,
    • Shahina Maqbool,
    • Tushar D. Bhagat,
    • Sonal Gupta,
    • Masako Suzuki,
    • Yiting Yu,
    • John M. Greally,
    • Ulrich Steidl,
    • James Bradner,
    • Meelad Dawlaty,
    • Lucy Godley,
    • Anirban Maitra,
    • and Amit Verma
    Genome Res. November 2017 27: 1830-1842; Published in Advance October 6, 2017, doi:10.1101/gr.222794.117
    ...of an oncometabolite that impedes TET function (Lu et al. 2013; Saha et al. 2014). The conclusions emerging from these data suggest that loss of 5-hmC is a cancer-specific “epigenotype” and, in fact, immunohistochemical studies on large panels of human archival cancers for global 5-hmC levels have shown reduced...
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