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  1. ...-value > 0.1). As there are few experimentally validated genomic elements, it is challenging to precisely measure the accuracy of annotations. Thus, to quantitatively assess these annotations, we evaluated their efficacy towards understanding tissue-specific gene regulation by performing three analyses...
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  2. ...-by-environment interactions can also alter gene expression patterns in a dynamic and tissue-specific manner without modifying the underlying nucleotide sequence; these effects are missed in a typical sequence-based method. Thus, an allele-specific approach is required to directly measure how cis-regulatory variation impacts...
  3. ...terminal poly(A) tracts but internal priming sites within longer transcripts, only a minority of which is encompassed by known genes. A significant proportion of these transcripts exhibit tissue-specific expression patterns, as well as dynamic changes in their expression in macrophages following...
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