Searching journal content for articles similar to Mao et al. 30 (1): 12.

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  1. Research: Ultraviolet damage and repair maps in Drosophila reveal the impact of domain-specific changes in nucleosome repeat length on repair efficiency
    • Benjamin Morledge-Hampton,
    • Kathiresan Selvam,
    • Manish Chauhan,
    • Alan G. Goodman,
    • and John J. Wyrick
    Genome Res. February 2025 35: 257-267; Published in Advance January 6, 2025, doi:10.1101/gr.279605.124
    ..., the wrapping of DNA around the histone octamer in individual nucleosomes significantly modulates UV damage formation and repair, generating nucleosome-associated patterns that correlate with somatic mutation rates in skin cancers (Brown et al. 2018; Pich et al. 2019). For example, the formation of UV...
  2. Method: Genome-wide maps of CPD deamination in yeast reveal the impact of DNA sequence context and nucleosome architecture on cytosine deamination rates
    • Marian F. Laughery,
    • Bastian Stark,
    • Benjamin Morledge-Hampton,
    • Steven A. Roberts,
    • and John J. Wyrick
    Genome Res. January 2026 36: 183-196; Published in Advance December 9, 2025, doi:10.1101/gr.280384.124
    ...of the DNA backbone is oriented either in toward the histone octamer (minor-in) or away from the histone octamer (minor-out) at 5 bp intervals. We and others have previously shown that both UV-induced CPD formation and somatic mutations in skin cancers are elevated at minor-out and suppressed at minor...
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  3. Research: Distinct roles for RSC and SWI/SNF chromatin remodelers in genomic excision repair
    • Kaitlynne A. Bohm,
    • Amelia J. Hodges,
    • Wioletta Czaja,
    • Kathiresan Selvam,
    • Michael J. Smerdon,
    • Peng Mao,
    • and John J. Wyrick
    Genome Res. June 2021 31: 1047-1059; Published in Advance May 17, 2021, doi:10.1101/gr.274373.120
    ...fraction of unrepaired CPDs near the central dyad axis of the nucleosome relative to the nucleosome edges or adjacent linker DNA (Fig. 2F), owing to GG-NER inhibition in nucleosomes. Moreover, repair inhibition was asymmetric, with more unrepaired damage accumulating on the slower-repairing 3′ side...
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