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Research: Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms
- Stephania Contreras Castillo,
- Bertille Montibus,
- Azucena Rocha,
- Will Duke,
- Ferdinand von Meyenn,
- Donal McLornan,
- Claire Harrison,
- Ann Mullally,
- Reiner Schulz,
- and Rebecca J. Oakey
Genome Res. August 2021 31: 1381-1394; Published in Advance July 9, 2021, doi:10.1101/gr.270066.120
...of action of HC.Enrichment analysis of up-regulated DEGs shared between CD34+ cells and neutrophils revealed the same terms as in mouse (Fig. 3D). TFs identified as regulators of these genes are RUNX1, SPI1, and TCF3. Other genes encoding TFs involved in hematopoiesis such as RARA, SPI1, CEBPB, and ZBTB7A...
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Research: TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells
- Kasper D. Rasmussen,
- Ivan Berest,
- Sandra Keβler,
- Koutarou Nishimura,
- Lucía Simón-Carrasco,
- George S. Vassiliou,
- Marianne T. Pedersen,
- Jesper Christensen,
- Judith B. Zaugg,
- and Kristian Helin
Genome Res. April 2019 29: 564-575; Published in Advance February 22, 2019, doi:10.1101/gr.239277.118
...are consistent with a direct role of DNA methylation and TET2 catalytic function to facilitate activity and/or expression of members of these TF clusters: (1) CEBPB has been reported to have a preference for binding to motifs with a methylated cytosine, thus potentially implicating TET2 as a factor...

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