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  1. ...where crossing-over events are rare within the centromeres (Dapper and Payseur 2017), and holocentric species (e.g., Caenorhabditis elegans), where the recombination rate increases with the relative distance from the center of the chromosomes (Prachumwat et al. 2004). In holocentric lineages...
  2. ...to see whether these chromosomes are acrocentric, which could lead to an overlap of the contact signal between centromeres with the contacts between subtelomeres and could mask centromere clustering.Changes in C3 strain chromatin structure during infection likely reflect transcriptional changesHi-C data...
  3. ...(Supplemental Fig. S2A). The frequency of contacts shows a very similar decay when the distances from telomeres or centromeres increase in wild-type cells. This probably reflects a similar flexibility of chromosome arms in these regions. In Sir3- or Sir3-A2Q-overexpressing cells, we observed a higher frequency...
  4. ...Francisco, California 94143, USA; 4Chan-Zuckerberg Biohub, San Francisco, California 94158, USA Corresponding author: katherine.pollard@gladstone.ucsf.eduAbstractRecombination enables reciprocal exchange of genomic information between parental chromosomes and successful segregation of homologous chromosomes...
  5. ...gigabases of sequence across 21 chromosomes. Meiotic crossovers are highly polarized along the chromosomes, with elevation in the gene-dense distal regions and suppression in the Gypsy retrotransposon-dense centromere-proximal regions. We profiled the genomic landscapes of the meiotic recombinase DMC1...
  6. ...responsible for conservation of the physical chromosomal locationof centromeres inC. albicans and C. dubliniensis. Interestingly, some of neocentromere hotspots in humans are sites for centromere repositioning during evolution (Ventura et al. 2004). Recombination coupled replication during gene conversion has...
  7. ...of recombination rate. However, on the population level, the linkage disequilibrium (LD)-based recombination frequencies across the cold regions are above zero, indicating that there is not a complete repression of recombination but rather a moderation of its frequency. The linkage map for Chromosome 8 is shown...
  8. ...Centromere reference models for human chromosomes X and Y satellite arrays Karen H. Miga 1 , 2 , Yulia Newton 2 , Miten Jain 2 , Nicolas Altemose 1 , Huntington F. Willard 1 and W. James Kent 2 , 3 1 Duke...
  9. ...segregation. During meiosis, centromeres are suppressed for inter-homolog crossover, as recombination in these regions can cause chromosome missegregation and aneuploidy. Plant centromeres are surrounded by transposon-dense pericentromeric heterochromatin that is epigenetically silenced by histone 3 lysine 9...
  10. ...-over and are thus thought to be largely devoid of DSBs. In many organisms, rDNA repeats are recombinationally suppressed to prevent chromosome rearrangements (Vader et al. 2011). In our laboratory strains of S. pombe, rDNA resides in ;65 tandem arrays on the ends of chromosome III, occupying;710 kb (M Eickbush, S...
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