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  1. ...in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana. PLoS Genet 8: e1002636. doi:10.1371/journal.pgen.1002636 ↵Da Ines O, Degroote F, Amiard S, Goubely C, Gallego ME, White CI. 2013a. Effects of XRCC2 and RAD51B mutations on somatic and meiotic recombination in Arabidopsis thaliana...
  2. ...fraction enrichment yields a negative score. Consistent with known replication timing patterns, pericentromeric heterochromatin is largely late-replicating in both GSC-like and CySC-like cells (Fig. 4B,C). On the other hand, in both cell types, the chromosomal arms of Chromosomes 2, 3, and the X replicate...
  3. ...1:1 orthologs in vertebrate s, including marmoset and mouse lemur (Table 1, GENCODE v44 and Ensembl release 110). The remaining 10 copies map on Chromosome 10, with the majority (7/10) at the q-arm pericentromeric region, precisely 10q11.22 (Table 1). They consist in four protein-coding genes, five...
  4. ...of meiotic folding are linked to recombination activity. We apply an integrative bioinformatics approach to analyze how three-dimensional (3D) chromosomal organization during meiosis relates to rates of double-strand-break (DSB) and crossover (CO) formation at PRDM9 binding peaks. We show that active...
  5. ...relatively enriched for crossovers near the center of the q-arm. Results for less frequent trisomies are depicted in Supplemental Figures S16 through S19.DiscussionMeiotic crossovers are necessary for ensuring accurate pairing and subsequent segregation of chromosomes following decades-long dictyate arrest...
  6. ...and a handful of consensuses have been reached. First, the size of a chromosome can affect the recombination rate, as correct segregation seems to be dependent on at least one recombination event per chromosome arm (Pardo-Manuel de Villena and Sapienza 2001; Smith and Nambiar 2020). A lower recombination rate...
  7. ...types; SCO: one crossover event on a chromosomal arm during one meiotic process; DCO: two crossover events in one meiotic process; TCO: three crossover events; QCO: four crossover events. (C) The recombination rate and 95% CI estimated from a Bayesian GLMM in which “population” and “chromosome” were...
  8. ...the observed maternal effect. The rDNA cluster resides on the same chromosome arm as the Psk-1 block (Espagne et al. 2008). Given that this arm is only ∼700 kb and the block itself is 113 kb, the Spok block insertion might interfere with recombination, either through changes of 3D chromosome structure...
  9. ...frequency (Westphal and Reuter 2002). Interestingly, the A. thaliana met1 and ddm1 CG methylation mutants associate with remodeling of meiotic recombination along chromosomes, with crossover increases in the chromosome arms and decreases across the pericentromeres (Colomé-Tatché et al. 2012; Melamed...
  10. ...of the long arm (∼129 Mb) adjacent to a region that is ampliconic in human but not in cat (Supplemental Table S4). These last five genes had no significant matches to the NCBI nonredundant protein sequence database.Comparative gene content and chromosome architectureWe also analyzed the X Chromosome assembly...
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