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Research: Cnidarian microRNAs frequently regulate targets by cleavage
- Yehu Moran,
- David Fredman,
- Daniela Praher,
- Xin Z. Li,
- Liang Meng Wee,
- Fabian Rentzsch,
- Phillip D. Zamore,
- Ulrich Technau,
- and Hervé Seitz
Genome Res. April 2014 24: 651-663; Published in Advance March 18, 2014, doi:10.1101/gr.162503.113
...patterns of Nematostella miRNAs and their targets, suggesting incoherent regulatory topologies (Fig. 5A). Two miRNAs, miR-2028 Figure 5. Regulation of miRNA targets and target conservation. (A) Expression of microRNAs and their targets as determined by double in situ hybridization. (B) A scheme showing...
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Perspective: Evolution under canalization and the dual roles of microRNAs—A hypothesis
- Chung-I Wu,
- Yang Shen,
- and Tian Tang
Genome Res. May 2009 19: 734-743; doi:10.1101/gr.084640.108
...phenotypes are stabilized within species. Evolution by natural selection can proceed efficiently only when phenotypes are canalized. The existence and identity of canalizing genes have thus been an important, but controversial topic. Recent evidence has increasingly hinted that microRNAs may be involved...
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Research: Death of new microRNA genes in Drosophila via gradual loss of fitness advantages
- Guang-An Lu,
- Yixin Zhao,
- Hao Yang,
- Ao Lan,
- Suhua Shi,
- Zhongqi Liufu,
- Yumei Huang,
- Tian Tang,
- Jin Xu,
- Xu Shen,
- and Chung-I Wu
Genome Res. September 2018 28: 1309-1318; Published in Advance July 26, 2018, doi:10.1101/gr.233809.117
..., Xiao J, Lyu Y, Chen Y, Shi S, Tang T, Wu CI. 2017. Redundant and incoherent regulations of multiple phenotypes suggest microRNAs’ role in stability control. Genome Res 27: 1665–1673. ↵Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2...
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Research: Impact of microRNA regulation on variation in human gene expression
- Jian Lu and
- Andrew G. Clark
Genome Res. July 2012 22: 1243-1254; Published in Advance March 28, 2012, doi:10.1101/gr.132514.111
...Impact of microRNA regulation on variation in human gene expression Jian Lu 1 and Andrew G. Clark 1 Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA Abstract MicroRNAs (miRNAs) are endogenously...
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Perspective: Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression
- Lesley T. MacNeil and
- Albertha J.M. Walhout
Genome Res. May 2011 21: 645-657; Published in Advance February 4, 2011, doi:10.1101/gr.097378.109
...of their downstream targets. Other regulators of gene expression include transcriptional cofactors that can physically interact with TFs, chromatin or components of the basal transcriptional machinery; RNA binding proteins that interact with mRNAs and regulate translation or mRNA stability; and microRNAs that repress...
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Research: Multidimensional regulation of gene expression in the C. elegans embryo
- John Isaac Murray,
- Thomas J. Boyle,
- Elicia Preston,
- Dionne Vafeados,
- Barbara Mericle,
- Peter Weisdepp,
- Zhongying Zhao,
- Zhirong Bao,
- Max Boeck,
- and Robert H. Waterston
Genome Res. July 2012 22: 1282-1294; Published in Advance April 16, 2012, doi:10.1101/gr.131920.111
...in cells that contribute to multiple tissue types and arise frommultiple lineages, ruling out the possibility that positional specificity results solely from single clones of expressing cells that are near eachother because of their tight ancestry. This type of pattern could regulate position...
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