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Research: Human-specific features of spatial gene expression and regulation in eight brain regions
- Chuan Xu,
- Qian Li,
- Olga Efimova,
- Liu He,
- Shoji Tatsumoto,
- Vita Stepanova,
- Takao Oishi,
- Toshifumi Udono,
- Katsushi Yamaguchi,
- Shuji Shigenobu,
- Akiyoshi Kakita,
- Hiroyuki Nawa,
- Philipp Khaitovich,
- and Yasuhiro Go
Genome Res. August 2018 28: 1097-1110; Published in Advance June 13, 2018, doi:10.1101/gr.231357.117
...in eight brain regions of humans, chimpanzees, gorillas, a gibbon, and macaques. An analysis of spatial transcriptome trajectories across eight brain regions in four primate species revealed 1851 genes showing human-specific transcriptome differences in one or multiple brain regions, in contrast to 240...
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ARTICLE: Regional Patterns of Gene Expression in Human and Chimpanzee Brains
- Philipp Khaitovich,
- Bjoern Muetzel,
- Xinwei She,
- Michael Lachmann,
- Ines Hellmann,
- Janko Dietzsch,
- Stephan Steigele,
- Hong-Hai Do,
- Gunter Weiss,
- Wolfgang Enard,
- Florian Heissig,
- Thomas Arendt,
- Kay Nieselt-Struwe,
- Evan E. Eichler,
- and Svante Pääbo
Genome Res. August 2004 14: 1462-1473; doi:10.1101/gr.2538704
...differences between the two species to be listed. However, to interpret these differences in terms of function, an important step is to know how gene expression has changed between humans and chimpanzees. Because several important phenotypic differences that distinguish humans and apes are associated...

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