Searching journal content for articles similar to Linhart et al. 22 (1): 76.

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  1. ...PGE accurately discovers some crucial TF motifs within prioritized cCREs and reveals the different regulatory types of these cCREs.Cell type–specific gene expression patterns are primarily determined through complex interactions between cis-regulatory elements (CREs) and transcriptional factors, playing...
  2. ...1 Functional genomics analysis of developing zebrafish and human endoderm reveals 1 highly conserved cis-regulatory modules acting during vertebrate organogenesis 2 3 Daniela M. Riley1,†, Randa Elsayed1,†, Mark D. Walsh2,†, Simaran Johal2, Ying Lin3,4, Harry 4 Walton1, Till Bretschneider5, Sascha...
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  3. ...pairs across replicates. (D) Annotations of all CTCF loops and differential loops (i.e., Wnt-ON/OFF-only, shared) as PP, PE, and EE interactions, where P and E denote promoter and enhancer, respectively. Benjamini–Hochberg adjusted P-values are depicted to highlight the significant differences...
  4. ...The role of transposon activity in shaping cis-regulatory element evolution after whole- duplication Øystein Monsen1,6, Lars Grønvold1,6, Alex Datsomor1, Thomas Harvey1, James Kijas2, Alexander Suh3,4,7, Torgeir R. Hvidsten5 and Simen Rød Sandve1 1Department of Animal and Aquacultural Sciences...
  5. ...Corresponding authors: gcooper@hudsonalpha.org, rmyers@hudsonalpha.orgAbstractDifferential gene expression in response to perturbations is mediated at least in part by changes in binding of transcription factors (TFs) and other proteins at specific genomic regions. Association of these cis-regulatory elements...
  6. ...in the significant CFM-associated variants (Supplemental Fig. 5B). Furthermore, on deeper examination, conditioning on all rare variants within a 1 kb region of all cis-regulatory (cis-reg) elements and the 11 presumptively pathogenic variants, a considerable number of variants remained significantly associated...
  7. ...and TAL1 at critical red blood cell-promoting genes (Hewitt et al. 2017; Zhou et al. 2023). Through the anemia recovery period, a central question emerges: What are the key cis-regulatory mechanisms, intrinsic to the erythroid precursors, that promote functional responses to acute stress? Using a model...
  8. ...Mariateresa Mazzetto, Lauren E. Gonzalez, Nancy Sanchez and Valerie Reinke Department of Genetics, Yale University, New Haven, Connecticut 06520, USA Corresponding author: valerie.reinke@yale.eduAbstractChromatin organization in the C. elegans germline is tightly regulated and critical for germ...
  9. ...that gained or lost activity and found none that were strongly associated with a specific pattern of response to the mutant genotypes. This suggests that changes in activity common to subsets of enhancers are not defined by the presence or absence of common motifs but instead by a more complex cis-regulatory...
  10. ...and which translated proteins result in plant immunity.Kozak sequences and the sequences nearby flanking TISs are well-known cis-regulatory signatures that enhance initiation at either AUG or nonAUG start codons (Kozak 1984, 1989). Here, we showed that Kozak motifs are preferentially associated with 5′ UTR...
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