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  1. ...sets for transcription factors from human, mouse, worm, and fly, as well as 10 target sets for microRNAs from human, and mouse from the metazoan target set compendium (Linhart et al. 2008). The plot is adapted from Linhart et al. (2008): The ‘‘Source’’ column indicates the experimental procedure...
  2. ...type, many of which nevertheless transcend cell types. Notably, the putative targets of shared binding rules in different cell types, while distinct, exhibit significant functional coherence. [Supplemental material is available for this article.] Transcriptional regulation is mediated by the binding...
  3. ...and microRNA motif discovery: The Amadeus platform and a compendium of metazoan target sets. Genome Res 18: 1180–1189. Macdonald LD, Knox A, Hansen D. 2008. Proteasomal regulation of the proliferation vs. meiotic entry decision in the Caenorhabditis elegans germ line. Genetics 180: 905–920. Makeev VJ...
  4. ...biomarkers. [Supplemental material is available for this article.] MicroRNAs (miRNAs) mediate degradation (Baek et al. 2008) or translational repression (Selbach et al. 2008) of gene transcripts associated with an array of biological processes including many of the hallmarks of cancer (Hanahan and Weinberg...
  5. ..., such as targeting by microRNAs (miRNAs), has been hindered by incomplete 39UTR annotation. In version 66 of Ensembl zebrafish genes (Feb. 2012), only 64.4% of the transcriptmodels have any 39UTR annotation, and only 28.9% of the genes havemore than one annotated 39 end. By comparison, over 96% of the human genes...
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