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  1. ..., catalyzed by the adenosine deaminase acting on RNA (ADAR) enzymes, is a posttranscriptional process that modifies RNA sequences and diversifies the transcriptome. ADARs bind to double-stranded RNA (dsRNA) and their specificity and efficiency are affected by the structural properties of these substructures...
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  2. ...Critical roles of long noncoding RNAs in Drosophila spermatogenesis Kejia Wen 1 , 6 , Lijuan Yang 1 , 2 , 6 , Tuanlin Xiong 1 , 6 , Chao Di 1 , Danhui Ma 1 , Menghua Wu 1 , Zhaoyu Xue 1 , Xuedi Zhang 1...
  3. ...of repetitive sequences to the spermatogenic transcriptome.We set out to create a more complete catalog of genes expressed during postreplicative spermatogenesis by isolating several specific cell types, performing a deep-coverage, paired-end RNA-seq analysis and generating a de novo annotation for genes...
  4. ...full-length circular RNA isoforms in human transcriptomes. Nat Commun 12: 266. doi:10.1038/s41467-020-20459-8 ↵Yang W, Du WW, Li X, Yee AJ, Yang BB. 2016. Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis. Oncogene 35...
  5. ...-encoded microproteins to the TP53 pathway, leading to a better understanding on the complexity of TP53 regulatory network.View larger version: In this window In a new window Figure 7. The expanded TP53 network. Network of the main TP53-inducible coding and noncoding RNAs in human cells as found in this screen. LncRNAs...
  6. .... 2012. 5′ End–centered expression profiling using cap-analysis gene expression and next-generation sequencing. Nat Protoc 7: 542–561. doi:10.1038/nprot.2012.005 ↵Uszczynska-Ratajczak B, Lagarde J, Frankish A, Guigó R, Johnson R. 2018. Towards a complete map of the human long non-coding RNA transcriptome...
  7. ...suitable for functional screenings of our lncRNA (62% found in the nuclear compartment). Besides, the dynamics of secondary effects mediated by different levels of knockdown from different technologies are likely to be observed as discordance when considering the whole transcriptome, where this kind...
  8. ...of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang 310058, China; 4Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorder, Hangzhou, Zhejiang 310058, China Corresponding authors: jun_ma@zju.edu.cn, feng_he@zju.edu.cnAbstractA class of noncoding RNAs...
  9. ...) and myelodysplastic syndromes (MDSs). These mutations have different effects on the disease prognosis with beneficial effect in MDS and worse prognosis in CLL patients. A full-length transcriptome approach can expand our knowledge on SF3B1 mutation effects on RNA splicing and its contribution to patient survival...
  10. ...inhibitor JQ1 (Fig. 4). PRO-seq allows high-resolution mapping of active RNA polymerases across the at both coding and noncoding regions and provides information on both the abundance and directionality of transcripts. Analysis of the transcriptome in LBH589-treated ESCs revealed that the majority of genes...
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