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Research: Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes
- Matthew R. Gazzara,
- Michael J. Mallory,
- Renat Roytenberg,
- John P. Lindberg,
- Anupama Jha,
- Kristen W. Lynch,
- and Yoseph Barash
Genome Res. August 2017 27: 1360-1370; Published in Advance May 16, 2017, doi:10.1101/gr.220517.117
...particularly linked to alternative splicing in many developmental and differentiation processes are CELF2 andRBFOX2. CELF2 is one of the sixmembers of the human family of CUGBP, ELAV-like family (CELF) proteins, while RBFOX2 is amember of the RBFOX family of RBPs,whichhas three paralogs in humans. Both...
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Research: Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans
- Bina Koterniak,
- Pallavi P. Pilaka,
- Xicotencatl Gracida,
- Lisa-Marie Schneider,
- Iva Pritišanac,
- Yun Zhang,
- and John A. Calarco
Genome Res. December 2020 30: 1766-1780; Published in Advance October 30, 2020, doi:10.1101/gr.267328.120
...sequences surrounding constitutively included exons (Fig. 6A). The resulting enriched sequences yield several expected motifs previously identified (Kabat et al. 2006; Ramani et al. 2011) and recognized by characterized RBPs, including FOX-1/Rbfox and the muscle-specific regulator SUP-12 (an ortholog of Rbm...
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