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Research: Genomic architecture constrained placental mammal X Chromosome evolution
- Wesley A. Brashear,
- Kevin R. Bredemeyer,
- and William J. Murphy
Genome Res. August 2021 31: 1353-1365; Published in Advance July 22, 2021, doi:10.1101/gr.275274.121
...hybrid, a phenomenon previously described in interspecific rodent crosses (Deng et al. 2015; Darrow et al. 2016).View larger version: In this window In a new window Figure 5. Spatial organization of loci previously associated with X Chromosome structural organization. (A) Hi-C contact map of the domestic...
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Research: The house fly Y Chromosome is young and minimally differentiated from its ancient X Chromosome partner
- Richard P. Meisel,
- Christopher A. Gonzales,
- and Hoang Luu
Genome Res. August 2017 27: 1417-1426; Published in Advance June 15, 2017, doi:10.1101/gr.215509.116
...member of a sex chromosome pair can experience evolutionary turnover while the other member remains unaffected. [Supplemental material is available for this article.] In organisms in which sex is determined by heritable genetic factors, sex determining loci can reside on sex chromosomes. Sex chromosome...
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Research: Evolutionary conservation of Y Chromosome ampliconic gene families despite extensive structural variation
- Wesley A. Brashear,
- Terje Raudsepp,
- and William J. Murphy
Genome Res. December 2018 28: 1841-1851; Published in Advance October 31, 2018, doi:10.1101/gr.237586.118
...ampliconic sequence dispersed across the domestic cat Y Chromosome, and identified the major ampliconic gene families and repeat units. We analyzed fluorescence in situ hybridization, qPCR, and whole- sequence data from 20 cat species and revealed that ampliconic gene families are conserved across the cat...
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METHODS: RHO—Radiation Hybrid Ordering
- Amir Ben-Dor,
- Benny Chor,
- and Dan Pelleg
Genome Res. March 1, 2000 10: 365-378; doi:10.1101/gr.10.3.365
..., Haifa 32000, Israel Radiation hybrid (RH) mapping is a somatic cell technique that is used for ordering markers along a chromosome and estimating the physical distances between them. With the advent of this mapping technique, analyzing the experimental data is becoming a challenging and demanding...
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Resource: A comprehensive molecular cytogenetic analysis of chromosome rearrangements in gibbons
- Oronzo Capozzi,
- Lucia Carbone,
- Roscoe R. Stanyon,
- Annamaria Marra,
- Fengtang Yang,
- Christopher W. Whelan,
- Pieter J. de Jong,
- Mariano Rocchi,
- and Nicoletta Archidiacono
Genome Res. December 2012 22: 2520-2528; Published in Advance August 14, 2012, doi:10.1101/gr.138651.112
...and obtaining preliminary physical maps of complex karyotypes such as that of HLE. Chromosomes of HLE were flow-sorted, the chromosomal DNAs labeled with fluorescent dyes (Cy3 and Cy5) and hybridized onto human BAC-arrays, as previously described (Carbone et al. 2006). In order to reduce the number...
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ARTICLE: A contiguous high-resolution radiation hybrid map of 44 loci from the distal portion of the long arm of human chromosome 5.
- J A Warrington and
- J J Wasmuth
Genome Res. July 1996 6: 628-632; doi:10.1101/gr.6.7.628
...A contiguous high-resolution radiation hybrid map of 44 loci from the distal portion of the long arm of human chromosome 5. J A Warrington and J J Wasmuth Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717, USA...
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LETTER: A Radiation Hybrid Map of the Cat Genome: Implications for Comparative Mapping
- William J. Murphy,
- Shan Sun,
- Zhang-qun Chen,
- Naoya Yuhki,
- Deborah Hirschmann,
- Marilyn Menotti-Raymond,
- and Stephen J. O'Brien
Genome Res. May 1, 2000 10: 691-702; doi:10.1101/gr.10.5.691
...of microsatellites in the domestic cat (Felis catus). Genomics 57 : 9 – 23 . ↵ Murphy W.J. , Menotti-Raymond M. , Lyons L.A. , Thompson M.A. , O'Brien S.J. ( 1999a ) Development of a feline whole radiation hybrid panel and comparative mapping of human chromosome 12 and 22 loci. Genomics 57 : 1 – 8 . ↵ Murphy W...
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RESEARCH: A Radiation Hybrid Map of Human Chromosome 5 with Integration of Cytogenetic, Genetic, and Transcript Maps
- John D. McPherson,
- Barbara Apostol,
- Caryn B. Wagner-McPherson,
- Simin Hakim,
- Richard G. Del Mastro,
- Naeema Aziz,
- Elizabeth Baer,
- Genalyn Gonzales,
- Mary Carol Krane,
- Rachelle Markovich,
- Peter Masny,
- Miguel Ortega,
- John Vu,
- Marco Vujicic,
- Deanna M. Church,
- Allan Segal,
- Deborah L. Grady,
- Robert K. Moyzis,
- M. Anne Spence,
- Michael Lovett,
- and John J. Wasmuth
Genome Res. September 1, 1997 7: 897-909; doi:10.1101/gr.7.9.897
...fluorescence in situ hybridization, and pulsed-field gel electrophoresis. Genomics 24 : 395 – 398 . ↵ Warrington J.A. , Wasmuth J.J. ( 1996 ) A contiguous high-resolution radiation hybrid map of 44 loci from the distal portion of the long arm of human chromosome 5. Genome Res. 6 : 628 – 632 . ↵ Warrington J...
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RESOURCE: The First-Generation Whole-Genome Radiation Hybrid Map in the Horse Identifies Conserved Segments in Human and Mouse Genomes
- Bhanu P. Chowdhary,
- Terje Raudsepp,
- Srinivas R. Kata,
- Glenda Goh,
- Lee V. Millon,
- Veronica Allan,
- François Piumi,
- Gérard Guérin,
- June Swinburne,
- Matthew Binns,
- Teri L. Lear,
- Jim Mickelson,
- James Murray,
- Douglas F. Antczak,
- James E. Womack,
- and Loren C. Skow
Genome Res. April 1, 2003 13: 742-751; doi:10.1101/gr.917503
...), and fluorescent in situ hybridization (FISH; e.g., Raudsepp et al. 1999 ; Godard et al. 2000 ; Lear et al. 2001 ; Mariat et al. 2001 ; Milenkovic et al. 2002 ). Among the recent prominent developments are the generation of preliminary radiation hybrid (RH) maps for chromosomes ECA1 and ECA10 ( Kiguwa et al. 2000...
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RESEARCH: An STS-Based Radiation Hybrid Map of the Human Genome
- Elizabeth A. Stewart,
- Kathleen B. McKusick,
- Amita Aggarwal,
- Ewa Bajorek,
- Shannon Brady,
- Angela Chu,
- Nicole Fang,
- David Hadley,
- Mark Harris,
- Sami Hussain,
- Richard Lee,
- Annu Maratukulam,
- Kyle O’Connor,
- Shanti Perkins,
- Mark Piercy,
- Fawn Qin,
- Tim Reif,
- Carla Sanders,
- Xiaohong She,
- Wei-Lin Sun,
- Poroshat Tabar,
- Susan Voyticky,
- Sid Cowles,
- Jian-Bing Fan,
- Chris Mader,
- John Quackenbush,
- Richard M. Myers,
- and David R. Cox
Genome Res. May 1, 1997 7: 422-433; doi:10.1101/gr.7.5.422
...linked with one or more markers with a two-point lod score between 5.99 and 3.0, and 34 markers (11%) were linked with a two-point lod score of &lt;3.0. All loci with lod scores of 6.0 or greater were assigned to the “correct” chromosome, as determined by using the NIGMS hybrid mapping panels. Loci...

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