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Research: LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly
- Jan Attig,
- George R. Young,
- Louise Hosie,
- David Perkins,
- Vesela Encheva-Yokoya,
- Jonathan P. Stoye,
- Ambrosius P. Snijders,
- Nicola Ternette,
- and George Kassiotis
Genome Res. October 2019 29: 1578-1590; Published in Advance September 19, 2019, doi:10.1101/gr.248922.119
.... Although protein products from these CLTs have not been previously observed, recent in-depth proteogenomic analysis of an Epstein-Barr virus–transformed B cell line (Laumont et al. 2016) or A431 cells and five healthy tissues (Zhu et al. 2018) provided evidence for the translation of similarly...
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Research: DNA methylation contributes to natural human variation
- Holger Heyn,
- Sebastian Moran,
- Irene Hernando-Herraez,
- Sergi Sayols,
- Antonio Gomez,
- Juan Sandoval,
- Dave Monk,
- Kenichiro Hata,
- Tomas Marques-Bonet,
- Liewei Wang,
- and Manel Esteller
Genome Res. September 2013 23: 1363-1372; Published in Advance August 1, 2013, doi:10.1101/gr.154187.112
...number variations (CNV; >5%) (Redon et al. 2006) in the detection sequence: Following these filters, from the originally printed 485,577 CpG sites in the microarray, we maintained 406,021 probes for subsequent analysis. Any DNA methylation variation introduced by Epstein-Barr virus (EBV) immortalization...
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