Searching journal content for articles similar to Lazar et al. 28 (7): 983.

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  1. ...to the underrepresentation of repetitive elements.View larger version: In this window In a new window Figure 2. Genome conservation and chromosomal rearrangements. (A) Genespace plot depicting chromosomal syntenies (of sequences >1 Mb) and rearrangements (of >5 genes) between turtles and chicken. Chromosomes are scaled...
  2. ...Biological Systems, University of California, Irvine, California 92697, USA Corresponding authors: liaoy12@uci.edu, jje@uci.eduAbstractTopologically associating domains (TADs) were recently identified as fundamental units of three-dimensional eukaryotic genomic organization, although our knowledge...
  3. .... 2004; Tuzun et al. 2005; Kidd et al. 2008; Mills et al. 2011; Eichler 2019). SVs can include “balanced” rearrangements, such as inversions and translocations, or genomic imbalances (duplications and deletions), commonly referred to as copy number variants (CNVs). Inversions represent an intriguing...
  4. ...-9051/17; www..org Genome Research 913 www..org The ability of PML to associate with defined areas of the is supported by its interaction with telomeres in mouse embryonic stem (ES) cells, where it enables ATRX-mediated H3.3 deposition and maintenance of heterochromatin (Wong et al. 2009, 2010; Chang et al...
  5. .... Integrative analysis of 111 reference human epis. Nature 518: 317–330. doi:10.1038/nature14248 ↵Lazar NH, Nevonen KA, O'Connell B, McCann C, O'Neill RJ, Green RE, Meyer TJ, Okhovat M, Carbone L. 2018. Epigenetic maintenance of topological domains in the highly rearranged gibbon . Genome Res 28: 983–997. doi...
  6. ...a similar coarse-grained view of 3D topology (Fig. 2A). However, in contrast to Hi-C, promoter CHi-C enables the identification of statistically significant long-range promoter interactions at the restriction fragment level (Fig. 2A). Genome-wide capture of promoter interactions Genome Research 583 www...
  7. ...breakpoint detection, we characterized the normal chromatin landscape of the human IGH locus and its dynamics after pathological genomic rearrangement. We detected an H3K4me3 broad domain (BD) within the IGH locus of healthy B cells that was absent in samples with IGH-CCND1 translocations. The appearance...
  8. ...-specific biology (Elsik et al. 2009; Groenen et al. 2012; Ullastres et al. 2014; Farré et al. 2016). The exact reason behind the genomic content differences between HSBs and EBRs is unknown, as well as the potential functional (nonmechanistic) role of chromosome rearrangements in evolution.It is well established...
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