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  1. ...in regions that are hard to genotype, such as 415 repetitive regions of the . Second, CRI-SPA-Map has high resolution due to short 416 introduced donor DNA tracts in local isolates and tracts that terminate near the targeted ORF in 417 distal isolates. Resolution can be further increased by targeting...
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  2. ...) (Dixon et al. 2012). These are contiguous chromosome regions which show enriched self-interactions and are thought to be associated with cis-regulatory mechanisms; they are often bounded by binding sites for the CCCTC-binding factor CTCF (Rao et al. 2014). ChIP-seq profiling of histone modifications...
  3. ...RNA-translation efficiency, or proteins associated with the targeted RNAs (Bass 2002; Tajaddod et al. 2015; Nishikura 2016; Licht et al. 2019).A-to-I editing is mediated by adenosine deaminases acting on RNAs (ADARs). In mammals, two catalytically active ADAR enzymes, ADAR (ADAR1) and ADARB1 (ADAR2) are known. Both enzymes...
  4. ...High-resolution nucleosome mapping reveals transcription-dependent promoter packaging Assaf Weiner 1 , Amanda Hughes 2 , Moran Yassour 1 , 3 , Oliver J. Rando 2 , 5 and Nir Friedman 1 , 4 , 5 1 School of Computer...
  5. ..., and thereby to reveal mechanisms underlying pig X and Y Chromosome evolution. Footnotes ↵ 5 Joint first authors [Supplemental material is available for this article.] Article published online before print. Article, supplemental material, and publication date are at http...
  6. ...populations and hybridized to the same high-resolution microarrays. The genomic region analyzed was a ;15 Mb segment centered around the X-inactivation center (Xic) ( built MM9 95–109 Mb), which represents ;10% of the X chromosome. Supplemental Figure S1 and the supporting Supplementalmaterial document...
  7. ...for pmemd simulations included in the AMBER 14 software package (Salomon-Ferrer et al. 2013). A high-resolution three-dimensional structure of human interleukin 21 (IL21) resolved by heteronuclear NMR spectroscopy (PDB code: 2OQP) was used (Bondensgaard et al. 2007).Polymorphism statistics, DFE, and Mc...
  8. ...A high-resolution map of nucleosome positioning on a fission yeast centromere Jun S. Song 1 , 2 , 4 , Xingkun Liu 3 , 4 , X. Shirley Liu 1 , and Xiangwei He 3 , 5 1 Department of Biostatistics and Computational Biology, Dana...
  9. ...Genome-wide, high-resolution DNA methylation profiling using bisulfite-mediated cytosine conversion Jon Reinders 1 , 3 , Céline Delucinge Vivier 2 , Grégory Theiler 1 , Didier Chollet 2 , Patrick Descombes 2 , and Jerzy Paszkowski 1...
  10. ...andWillard 1995; Roizès 2006), and in whole- data from diploid s; accordingly, it is difficult to infer the long-range sequence organization and assign sequence variants to a single array. The X and Y chromosomes, represented as haploid arrays in the male , offer a unique opportunity a for high-resolution...
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