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  1. ..., Barcelona 08034, Spain; 3Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, California 94720, USA; 4Genomics Institute, University of California, Santa Cruz, Santa Cruz, California 95060, USA; 5Institute for Computational and Mathematical Engineering...
  2. ...Rmethod demonstrated superiority in 89% of the type 3 traits (eight out of nine), attributed to a rapid decline in the proportion of heritability explained by QTL. The GBLUP method did not yield the optimal results for any trait. Evaluating the impact of parameters on different models using simulated data...
  3. ...it an encouraging instrument for rapid clinical implementation (Gorzynski et al. 2024; Smolka et al. 2024). Despite recent advances, several factors still limit the adoption of ONT sequencing in genomics and clinical research. Homopolymer regions continue to increase error rates, particularly in LRS, although...
  4. ...this growing volume of bacterial data, providing rapid results, but that remain simple so they can be used without highly trained bioinformaticians, expensive data analysis, and long-term storage and processing of large files. Here we describe split k-mer analysis (SKA2), a method that supports both reference...
  5. ...in an accessible chromatin state, 456 allowing for rapid transcriptional activation upon stimulation (Bahrami and Diablos, 2016). 457 Alternatively, these genes may be regulated post-transcriptionally following poly I:C 458 stimulation, a mechanism often observed in innate immune responses, which could involve 459...
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  6. ...Ruhollah Shemirani1, Gillian M. Belbin1,9, Sinead Cullina1,2, Christa Caggiano1, Christopher R. Gignoux3,4, Noah Zaitlen5,6,7 and Eimear E. Kenny1,2,8 1Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA; 2Department of Genetics and Genomic Sciences...
  7. ...a fraction of infections, researchers turned to phylodynamic approaches to understand SARS-CoV-2's population structure (Grenfell et al. 2004; Volz et al. 2013; Chiara et al. 2023). Genomics was at the center of this effort. Rapid sequencing and whole phylogeny updated in quasi-real time enabled surveillance...
  8. ...Genome Res GENOME Genome Research Genome Res. Genome Res 1088-9051 1549-5469 Cold Spring Harbor Laboratory Press 9509184 10.1101/gr.280534.125 ;gr.280534.125v1 ;gr.280534.125 gr.280534.125 gr.280534.125 Research Abaev-Schneiderman et al. ACTB methylation regulates transcription 1 The Shraga Segal...
  9. ...these platforms for clinical use. Although the rapid evolution of long-read technologies poses challenges for clinical validation, successful diagnostic cases in research settings have demonstrated their potential to resolve previously unsolved cases, particularly those involving complex SVs or repeat expansions...
  10. ...of rapid fixation of the sex-linked meiotic driver. If stronger female bias keeps being adaptive, selection will lead to an increasingly female-biased sex ratio following transition to sociality. The results from the PSMC analyses showing that NeX/NeA continues to increase after the transition to sociality...
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