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Method: Modeling leaderless transcription and atypical genes results in more accurate gene prediction in prokaryotes
- Alexandre Lomsadze,
- Karl Gemayel,
- Shiyuyun Tang,
- and Mark Borodovsky
Genome Res. July 2018 28: 1079-1089; Published in Advance May 17, 2018, doi:10.1101/gr.230615.117
...of the prokaryotic organization, promoters precede operons and ribosome binding sites (RBSs) with Shine-Dalgarno consensus precede genes. However, recent experimental research suggesting a more diverse view motivated us to develop an algorithm with improved gene-finding accuracy. We describe GeneMarkS-2, an ab...
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Research: Trans-splicing enhances translational efficiency in C. elegans
- Yu-Fei Yang,
- Xiaoqing Zhang,
- Xuehua Ma,
- Taolan Zhao,
- Qiushi Sun,
- Qing Huan,
- Shaohuan Wu,
- Zhuo Du,
- and Wenfeng Qian
Genome Res. September 2017 27: 1525-1535; Published in Advance July 6, 2017, doi:10.1101/gr.202150.115
...that SL1 trans-splicing likely enhances translational efficiency by shortening the native 5′ UTRs, hence reducing the presence of upstream start codons (uAUG) and weakening mRNA secondary structures. Taken together, our study elucidates the global function of trans-splicing in enhancing translational...

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