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Editorial: New frontiers in single-cell genomics
- Nicholas E. Navin,
- Orit Rozenblatt-Rosen,
- and Nancy R. Zhang
Genome Res. October 2021 31: ix-x; doi:10.1101/gr.276129.121
.... 2021. Profiling single-cell histone modifications using indexing chromatin immunocleavage sequencing. Genome Res (this issue) 31: 1831–1842. doi:10.1101/gr.260893.120 ↵Lakkis J, Wang D, Zhang Y, Hu G, Wang K, Pan H, Ungar L, Reilly MP, Li X, Li M. 2021. A joint deep learning model enables simultaneous...
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Method: Iterative epigenomic analyses in the same single cell
- Hidetaka Ohnuki,
- David J. Venzon,
- Alexei Lobanov,
- and Giovanna Tosato
Genome Res. October 2021 31: 1819-1830; Published in Advance February 24, 2021, doi:10.1101/gr.269068.120
...). These observations suggest that characterization of multiple histone modifications and DNA-binding proteins may have a similar potential even at a single cell level. However, technical limitations in current single-cell epigenomic technologies impede a broad profiling of histone modifications, DNA modifications...

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