Searching journal content for articles similar to Koterniak et al. 30 (12): 1766.

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  1. ...also analyze the global data to examine important TF features and relationships, including the correlation of cobinding by TFs at target genes, the frequency of high TF occupancy sites in the , and the impact of underlying sequence motifs and chromatin accessibility on TF binding. Finally, we begin...
  2. ...or in the context of cell culture systems, global studies in complex organisms will be necessary to establish the extent of developmentally regulated zygotic decay.The nematode Caenorhabditis elegans provides an ideal system for the global study of zygotic mRNA decay owing to its invariant cell lineage...
  3. ....0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.References ↵Allen MA, Hillier LW, Waterston RH, Blumenthal T. 2011. A global analysis of C. elegans trans-splicing. Genome Res 21: 255–264. ↵Amrane S, Rebora K, Zniber I, Dupuy D, Mackereth CD. 2014. Backbone-independent nucleic acid...
  4. ..., Finland (Dfc). Colors represent the climate zones according to the Köppen–Geiger climate distribution (Peel et al. 2007). (B) Pipeline to detect chimeric transcripts. (C) Contribution of chimeric gene–TE transcripts to the total transcriptome and the body part–specific transcriptome globally and by strain...
  5. ...and TNS with beta integrin. In light of these findings, we propose that alternate use of micro-exons often alters local binding-site specificities, whereas the inclusion of longer AS exons may more substantially alter global protein structure. Although we show that several AS micro-exons are likely...
  6. ...switching of mutually exclusive alternative splicing in vivo. Genes Dev 22: 360–374. Pan Q, Shai O,Misquitta C, ZhangW, Saltzman AL, Mohammad N, Babak T, Siu H, Hughes TR, Morris QD, et al. 2004. Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform...
  7. ...efficiency extends the exposure of intronic and exonic sequences to ADAR enzymes. Lack of splicing factors NOVA1 or NOVA2 changes global editing levels, demonstrating that alternative splicing factors can modulate RNA editing. Finally, we show that intron retention rates correlate with editing levels across...
  8. ...in disease. We sought to analyze the global splicing regulatory network of CELF2 in human T cells, a well-studied splicing regulator critical to T cell development and function. By integrating high-throughput sequencing data for binding and splicing quantification with sequence features and probabilistic...
  9. ...into the regulatory network of that factor, as we find that the transcription factor UNC-62 has distinct binding profiles at different stages due to distinct cofactor co-association as well as tissue-specific alternative splicing. Finally, we describe an approach to infer potential regulators of gene expression...
  10. ...). Each of these features might be explained by the presence of strong regulatory constraints, such as shared enhancers or global control regions (de la Calle-Mustienes et al. 2005; Irimia et al. 2008). Consistently, functional studies in vertebrates and flies have shown that some regulatory elements...
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