Searching journal content for articles similar to Komura et al. 16 (12): 1575.

Displaying results 1-10 of 95
For checked items
  1. ...Genome-wide Detection of Allelic Imbalance Using Human SNPs and High-density DNA Arrays Rui Mei 1 , 7 , Patricia C. Galipeau 2 , Cynthia Prass 3 , Anthony Berno 1 , Ghassan Ghandour 4 , Nila Patil 1 , Roger K. Wolff 3...
  2. ...that was used to identify the SNPs. A total of 98.7% (74/75) of these SNPs were confirmed using both DNA dideoxynucleotide sequencing and the VDA methodologies. With flexible sample preparation, high-density oligonucleotide arrays can be tailored for even larger scale genome-wide SNP discovery as well...
  3. .... ↵ Chakravarti A. ( 1999 ) Population genetics–making sense out of sequence. Nature Genet. 21 : 56 – 60 . ↵ Chee M. , Yang R. , Hubbell E. , Berno A. , Huang X.C. , Stern D. , Winkler J. , Lockhart D.J. , Morris M.S. , Fodor S.P. ( 1996 ) Accessing genetic information with high-density DNA arrays. Science 274...
  4. ...investigates the mechanisms by which mammalian cells coordinate DNA replication with transcription and chromatin assembly. In yeast, DNA replication initiates within nucleosome-free regions, but studies in mammalian cells have not revealed a similar relationship. Here, we have used genome-wide massively...
  5. ...al. 2008). Changes in DNA content and structure are a significant source of genetic and phenotypic variation among individuals (Feuk et al. 2006; Beckmann et al. 2007; Conrad and Antonarakis 2007; McCarroll and Altshuler 2007). These types of structural variations ranging from 1 kilobase (kb) to 5...
  6. ...-base detection of DNA methylation A number of methods have been developed for -wide detection of sites of DNA methylation (for review, see Esteller 2007 ; Beck and Rakyan 2008 ). Widely used approaches include enzymatic digestion of methylated DNA followed by hybridization to high-density oligonucleotide arrays...
  7. ...and microsatellite maps . BMC Genet. 6 : S34 , doi: 10.1186/1471-2156-6-S1-S34 . ↵ Huang, J. , Wei, W. , Zhang, J. , Liu, G. , Bignell, G.R. , Stratton, M.R. , Futreal, P.A. , Wooster, R. , Jones, K.W. , Shapero, M.H. ( 2004 ) Whole DNA copy number changes identified by high density oligonucleotide arrays . Hum...
  8. ...( Mockler et al. 2005 ). Moreover, large fragments also increase the likelihood of co-precipitating adjacent, unmethylated DNA, causing false-positive signals, especially on high-density oligonucleotide arrays. Finally, these approaches require relatively large amounts of input DNA (2–20 μg); thus...
  9. ..., Addenbrooke's Hospital, Cambridge CB2 2XZ, UK Abstract Genomic copy number alterations are a feature of many human diseases including cancer. We have evaluated the effectiveness of an oligonucleotide array, originally designed to detect single-nucleotide polymorphisms, to assess DNA copy number. We...
  10. ..., the input data representing the observed allelic counts in the tumor DNA are discrete in nature and thus are not well suited to commonly used Gaussian or Student’s-t distributions that are often used for the analogous problem in continuous array data. Third, the allelic count data from the tumor DNAwill...
For checked items

Preprint Server