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Review: The superpowers of imprinting control regions
- Bertille Montibus,
- Franck Court,
- and Philippe Arnaud
Genome Res. January 2026 36: 1-19; Published in Advance December 10, 2025, doi:10.1101/gr.281215.125
...). Gametogenesis reprogramming results in a global erasure of DNA methylation in primordial germ cells (PGCs), affecting virtually all epigenetic-based developmental processes, with only ∼3.5% of CpG sites remaining methylated (Kobayashi et al. 2013). This includes genomic imprinting, as methylation is lost at all...
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Research: Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites
- Fiorella C. Grandi,
- James M. Rosser,
- Simon J. Newkirk,
- Jun Yin,
- Xiaoling Jiang,
- Zhuo Xing,
- Leanne Whitmore,
- Sanum Bashir,
- Zoltán Ivics,
- Zsuzsanna Izsvák,
- Ping Ye,
- Y. Eugene Yu,
- and Wenfeng An
Genome Res. August 2015 25: 1135-1146; Published in Advance May 20, 2015, doi:10.1101/gr.185132.114
...distinguish future-low CGIs from future-high CGIs during two episodes of DNA methylation reprogrammingDNA methylation undergoes -wide reprogramming during both early embryogenesis and germ cell specification (Lee et al. 2014). We reasoned that important insights into the genesis of high and low CGIs could...
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